Cardiac and cerebral vascular disease treating pharmaceutical composition
A technology of cardiovascular and cerebrovascular diseases and compositions, which is applied in the direction of cardiovascular system diseases, drug combinations, active ingredients of hydroxyl compounds, etc., can solve problems such as inability to take care of oneself, relatives and social burdens, and achieve quality control, easy industrialization, multi-benefit effect
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Embodiment 1
[0089] Preparation of tanshinone extract: Take the pulverized salvia miltiorrhiza and put it into CO 2 The extraction kettle in the extraction equipment, when all parts of the system reach the set temperature, the pressure of the extraction kettle is increased to the set pressure. Add 95% ethanol solution to the system according to the set flow rate, and CO 2 After mixing, the dynamic extraction is circulated in the whole system; the extraction conditions are extraction pressure 20MPa, extraction temperature 45°C, separation temperature 35°C, and ethanol flow rate 1.0mL / min; after the extraction is completed, the extract is released, concentrated, and vacuum-dried to obtain Tanshinone extract, its total tanshinone content is 64%. The extracted medicinal material residue is used for future use.
[0090] Preparation of the total phenolic acid extract of Salvia miltiorrhiza: take the medicinal material residue after extracting tanshinone, and obtain it according to the preparati...
Embodiment 2
[0095] Preparation of tanshinone extract: take Danshen decoction pieces or pulverized Danshen, add 95% ethanol to soak for 2 hours, then reflux extraction at 75°C for 3 times, each time the amount of solvent is 5 times the weight of the crude drug, and the extraction time is 60 minutes, 30 minutes and 30 minutes; combine the extracts, and concentrate the extracts under reduced pressure below 50°C to 1 / 40 of the original volume to obtain a concentrate; add 3 times the volume of water to the concentrate, let it stand for 12 hours, and filter; Dry below 50°C to obtain tanshinone extract, the total tanshinone content is 61%. The extracted medicinal material residue is used for future use.
[0096] Preparation of the total phenolic acid extract of Salvia miltiorrhiza: take the medicinal material residue after extracting tanshinone, and obtain it according to the preparation method in Example 1 of Chinese patent application CN1384090A. The total phenolic acid content of the salvia m...
Embodiment 3
[0101] Preparation of tanshinone extract: Take the pulverized salvia miltiorrhiza and put it into CO 2 The extraction kettle in the extraction equipment, when all parts of the system reach the set temperature, the pressure of the extraction kettle is increased to the set pressure. Add 90% ethanol solution to the system according to the set flow rate, and CO 2 After mixing, the dynamic extraction is circulated in the whole system; the extraction conditions are extraction pressure 250MPa, extraction temperature 45°C, separation temperature 35°C, and ethanol flow rate 0.8mL / min; after the extraction is completed, the extract is released, concentrated, and vacuum-dried to obtain Tanshinone extract, its total tanshinone content is 59%. The extracted medicinal material residue is used for future use.
[0102] Preparation of the total phenolic acid extract of Salvia miltiorrhiza: take the medicinal material residue after extracting tanshinone, and obtain it according to the preparat...
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