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Medicinal composition, preparation method and quality control method

A composition and drug technology, applied in the directions of drug combination, testing drug preparation, drug formula, etc., to achieve the effects of protecting ischemic myocardium, increasing blood flow, and being convenient to use and carry

Inactive Publication Date: 2007-02-21
BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there are no reports of preparations that are compatible with both

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: Preparation of Acanthopanax senticosus extract: get 10 parts of Acanthopanax senticosus (parts are: kilogram or gram)

[0023] Take Acanthopanax, crush it into coarse powder, add 7 times the amount of 75% ethanol, reflux extraction for 12 hours, filter, recover ethanol from the filtrate, concentrate it into an extract, and obtain the Acanthopanax extract.

Embodiment 2

[0024] Embodiment 2: preparation of Acanthopanax senticosus extract: 1000 parts of Acanthopanax senticosus (part is: kilogram or gram)

[0025] Take Acanthopanax coarse powder, add 8 times the amount of water to decoct, the decoction is concentrated, pass through the pre-treated macroporous adsorption resin column, the flow rate is 10ml / min, then rinse with an appropriate amount of water for injection, and then wash with 75% ethanol Remove, collect the eluent, fill until the eluent is colorless, recover ethanol, and dilute with water, refrigerate, filter, and concentrate the filtrate to obtain the Acanthopanax Radix Extract.

Embodiment 3

[0026] Embodiment 3: preparation of Acanthopanax senticosus extract: 3000 parts of Acanthopanax senticosus (part is: kilogram or gram)

[0027] Take Acanthopanax, add water and decoct twice, the first time is 3 hours, the second time is 2 hours, combine the decoction, filter, the filtrate is concentrated into clear paste (water content is 30%), take Acanthopanax clear paste, Add a little boiling water to dissolve, slowly add 3 times the amount of ethanol under stirring, let it stand for 6 hours, take the supernatant, and filter; add 2 times the amount of ethanol to the residue, stir, let it stand, take the supernatant, filter, and combine Secondary alcohol washing solution, recovering ethanol and concentrating to a relative density of 1.15 (80°C) to obtain the extract of Acanthopanax senticosus.

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PUM

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Abstract

A composite medicine in the form of injection or orally taken medicine for treating cardiovascular and cerebrovascular diseases, such as coronary heart disease, angina pectoris, apoplexy sequelae, cerebral thrombus, etc, is prepared from acanthopanax bark or its extract and dipyridamole. Its preparing process and quality control method are also disclosed.

Description

technical field [0001] The invention provides a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, as well as a preparation method and a quality control method of the composition, belonging to the technical field of medicines. technical background [0002] At present, about 4 million people die from cardiovascular and cerebrovascular diseases in my country every year, accounting for more than 3 / 5 of the death toll, and it has become the primary factor threatening human health. Although there are a large number of Chinese and Western medicine interviews at present, with the continuous change of disease spectrum and the arrival of aging age, the current medicine continues to show its limitations. Therefore, research and development of medicines for the treatment of cardiovascular and cerebrovascular diseases are always Become the focus and hot spot of people's attention. In the prior art, it has been proved by modern pharmacology that Acantho...

Claims

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Application Information

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IPC IPC(8): A61K36/254A61K9/00A61P9/10A61P7/02G01N33/15A61K31/519
Inventor 于文风
Owner BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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