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Coffee beverage composition

A technology of coffee beverage and composition, which is applied in the direction of coffee extraction and removal of impurities, etc., which can solve the problems of rising blood pressure and not recognizing the effect of lowering blood pressure

Active Publication Date: 2007-02-07
KAO CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is also a report that not only does not recognize the clear blood pressure lowering effect of the well-known coffee drink containing a large amount of chlorogenic acids, but also thinks that it will increase blood pressure (Non-Patent Document 1)

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] (a) The coffee drink composition of this invention is manufactured as follows. Put 2.5 g of instant coffee (decaffeinated Nescafé) on a column filled with 500 g of ODS filler (octadecyl silylated silica gel) (YMC GEL ODS-A pore size 6 nm particle size 150 μm) Middle and 6 L of 0.5% acetic acid water were used to elute components containing hydroxyhydroquinone, and 6 L of methanol to elute components containing other components of chlorogenic acids. Methanol in Fraction A, which will contain other components of chlorogenic acids, was completely removed by freeze-drying. 0.933 g of component A was obtained from 2.5 g of instant coffee.

[0052] (b) The analysis methods of chlorogenic acids and hydroxyhydroquinone in the coffee drink composition are as follows. The following analysis conditions were defined as analysis conditions A. As an analytical instrument, HPLC (Shimadzu Corporation) was used. The model numbers of the structural units of the device are as follows....

Embodiment 2

[0083] Evaluation of blood pressure lowering

[0084] i) Experimental materials and methods

[0085] (a) Blood pressure was measured for 12-week-old male spontaneously hypertensive rats (SHR) preliminarily for 5 consecutive days using a commercially available non-observing blood pressure measuring device for rats (manufactured by Softron Co., Ltd.). After the rats were sufficiently accustomed to the blood pressure operation, an evaluation test was performed. All the rats were raised under the conditions of temperature 25±1°C, relative humidity 55±10%, and lighting time 12 hours (7:00 am to 7:00 pm) (in the breeding room in the rat area).

[0086] (b) Administration method and dosage: In the test group, component A obtained by removing hydroxyhydroquinone from instant coffee was used as the administration material. The control group used instant coffee. Component A instant coffee was respectively dissolved in physiological saline to prepare a dosage of 200 mg / kg as the total...

Embodiment 3

[0094] Evaluation of blood pressure lowering

[0095] i) Experimental materials and methods

[0096] (a) In the same manner as in Example 2, 12-week-old male spontaneously hypertensive rats (SHR) were preliminarily bred.

[0097] (b) Administration method and dosage: Physiological saline was orally administered to the control group. For the comparison group, a green coffee bean extract (Fre-Bar-Holder-FH1041: manufactured by Hasegawa Fragrance Co., Ltd.) containing chlorogenic acid as the main component was used. The dosage was made to be 300 mg / kg as the total chlorogenic acid amount. In the test group 1, FH1041 was prepared to be 300 mg / kg as the total chlorogenic acid amount, and hydroxyhydroquinone was prepared to be administered at 0.03 mg / kg (0.01% relative to the total chlorogenic acid amount). In the following test group 2, FH1041 was prepared as 300 mg / kg of total chlorogenic acid content and 0.3 mg / kg of hydroxyhydroquinone (0.1% relative to the total chlorogenic ...

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Abstract

Provided is a coffee composition having an excellent hypotensive effect. The coffee composition has the following components (A) and (B): 0.01 to 1% by weight of chlorogenic acids (A), less than 0.1% by weight, based on the weight of the chlorogenic acids, of (B) hydroxyhydroquinone.

Description

technical field [0001] The present invention relates to a coffee beverage composition having hypotensive effect. Background technique [0002] As therapeutic drugs for hypertension, various neuroleptics acting on the regulatory system dependent on nerve factors, ACE inhibitors acting on the regulating system related to humoral factors, AT receptor antagonists, Drugs such as Ca antagonists related to the regulation system of vascular endothelial substances, and antihypertensive diuretics related to the humoral regulation system in the kidney are mainly used in medical institutions for severe hypertensive patients. However, the medicines currently used for the purpose of treating hypertension have sufficient effectiveness but also have a lot of side effects, which impose a great burden on patients. [0003] In addition, general life-improving treatments such as diet therapy, exercise therapy, and restrictions on drinking and smoking are widely applied to people with mild high...

Claims

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Application Information

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IPC IPC(8): A23F5/24A23F5/16
Inventor 藤井明彦铃木淳大南英雄落合龙史渋谷祐辅
Owner KAO CORP
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