EphA2 agonistic monoclonal antibodies and methods of use thereof
A technology of antibodies and human antibodies, applied in the fields of antibodies, chemical instruments and methods, anti-receptors/cell surface antigens/cell surface determinant immunoglobulins, etc., can solve problems such as difficult standard chemotherapy for cancer
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[0071] The present invention is based in part on the inventors' discovery that EphA2 monoclonal antibodies can suppress the phenotype of cancer cells. Reducing the activity of EphA2 selectively inhibits the growth of malignant cancer cells. EphA2 activity can be reduced with EphA2 agonistic monoclonal antibodies. While not wishing to be bound by any mechanism of action, this inhibition of cancer cell growth may be achieved by stimulating (ie, stimulating) EphA2 signaling to cause phosphorylation of EphA2 leading to its degradation. Reduced cancer cell growth was due to reduced EphA2 levels and ligand-independent EphA2 signaling.
[0072] Accordingly, the present invention relates to methods and compositions for the treatment, inhibition and management of cancer, particularly metastatic cancer. Particular aspects of the invention relate to methods and compositions comprising compounds that inhibit the proliferation and invasion of cancer cells, particularly those that overexp...
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