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Medicinal composition for treating cardiovascular disease, its making method and use

A composition and cardiovascular technology, which is applied in cardiovascular system diseases, drug combination, drug delivery, etc., can solve problems such as different compatibility of active ingredients, difficulty in product quality control, and instability of saponins

Inactive Publication Date: 2007-01-17
CHENGDU DIKANG PHARMA INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this method has simple manufacturing process and low cost, there are problems that cannot be ignored: (1) the prepared preparation is a yellowish-brown liquid containing a large amount of pigments; (2) the effective part saponin of the medicine is unstable in water, Easy to hydrolyze, often cause precipitation or turbidity in the preparation, directly affect the quality of the preparation
(3) The quality standard of the preparation is not perfect, and there are few controllable indicators. There are only qualitative identification of saponins and determination of total saponin content, but no determination indicators of active ingredient content. The current situation of traditional Chinese medicine preparations does not match
And although the raw materials are the same, due to different extraction methods and different combinations of active ingredients, there are large differences in drug efficacy. Therefore, it is necessary to study a drug with definite curative effect, clear ingredients, reasonable formula and controllable quality.

Method used

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  • Medicinal composition for treating cardiovascular disease, its making method and use

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1 pharmaceutical preparation method of the present invention

[0035] 1. Pretreatment and extraction of medicinal materials

[0036] The qualified red ginseng and Ophiopogon japonicus medicinal materials are selected, washed, dried and crushed into flakes or granules respectively.

[0037] Weigh red and add water and boil for 1-4 hours, filter; add 8-20 times of water to the medicine residue, boil for 1-4 hours, filter; add 8-20 times of water to the medicine residue, boil for 1-3 hours hours, filter, combine the filtrates, and centrifuge to remove the precipitate to obtain the ginseng water extract.

[0038] Weigh a certain amount of Ophiopogon japonicus, add water to boil, keep warm for 1-4 hours, filter; add 15-30 times of water to the dregs, boil, keep warm at 50-95°C for 1-2 hours, filter; add 15-30 times to the dregs After the water is boiled, it is kept at 50-95° C. for 1-3 hours, filtered, the filtrates are combined, and the precipitate is removed b...

Embodiment 2

[0052] Embodiment 2 The preparation of drug freeze-dried powder injection of the present invention

[0053] 1. Prescription

[0054] Ginsenoside 6g prepared in Example 1

[0055] Ophiopogon saponin 0.6g prepared in embodiment 1

[0056] Accessories 100g

[0057] Add water for injection to 500ml

[0058] 2. Preparation method

[0059] Accurately weigh the above-mentioned ginsenosides and Ophiopogon japonicus extracts, add water to dissolve them under sterile conditions, and set aside. In addition, weigh the calculated excipients (the excipients are commonly used excipients for powder injections) and place them in a sterile container, add water to dissolve. The two solutions were fully mixed under gentle stirring, and water was added to make up to 500-1000ml. After being filtered and sterilized by a microporous membrane, it is divided into sterilized freeze-dried vials, 2-20ml / bottle, freeze-dried, plugged and capped.

Embodiment 3

[0060] Embodiment 3 Preparation of drug freeze-dried powder injection of the present invention

[0061] prescription

[0062] Ginsenoside 24g prepared in embodiment 1

[0063] Ophiopogon saponin 0.6g prepared in embodiment 1

[0064] Accessories 150g

[0065] Add water for injection to 1000ml

[0066] Prepared according to the method of Example 2.

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Abstract

A medicinal composition in the form of injection for treating cardiovascular disease contains ginsenoside, ophiopogon saponin, and pharmacologically acceptable additives. Its preparing process is also disclosed.

Description

technical field [0001] The invention provides a pharmaceutical composition for treating cardiovascular diseases, a preparation method and application thereof. Specifically, it is a pharmaceutical composition prepared from active ingredients in Chinese medicinal materials. Background technique [0002] Cardiovascular and cerebrovascular diseases are one of the diseases that are seriously threatening human life and health. Cardiovascular and cerebrovascular diseases after middle age mainly refer to coronary heart disease and stroke (also known as cerebral apoplexy). These two common diseases and frequently-occurring diseases pose an increasing threat to the health of our population. According to the "1998 Statistical Bulletin on the Development of National Health Services" issued by the Ministry of Health, in 1998, the mortality rate of cardiovascular disease in my country was 244.3 / 100,000 in urban population and 193.1 / 100,000 in rural population, both of which are listed a...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61K31/7048A61K9/08A61K9/14A61P9/10A61P9/00
Inventor 曾雁鸣银海孙继林
Owner CHENGDU DIKANG PHARMA INST
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