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Catalyst for synthesis of 2-and 4-picolines, process for preparing 2- and 4-picoline and process for preparing the catalyst

A technology for methylpyridine and catalyst, which is applied in the field of preparation of 2-methylpyridine and 4-methylpyridine and catalyst, can solve the problems of low product yield, environmental pollution and the like, achieves simple and economical method, and avoids environmental problems. The effect of pollution

Inactive Publication Date: 2006-12-27
COUNCIL OF SCI & IND RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Low yield of desired product
Because these pathways use toxic ThO 2 and CdO, so by using said catalyst to make pyridine base cause environmental pollution

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Catalyst preparation: silica gel with a particle size of 6 to 14 meshes is used as a silicon-based carrier (silica support)

[0031] Phosphotungstic acid (10 g) was dissolved in water (25 ml), and the solution was mixed with silica gel (100 g). The slurry was stirred to obtain a homogeneous impregnation, dried in air at 200 to 250°C for 1 hour, then at 400°C for 1 hour, and finally cooled to room temperature in a desiccator. This catalyst is used for the reaction of acetaldehyde and ammonia.

[0032] The experiments were carried out in a downflow glass reactor with an inner diameter of 2 cm and sufficient length to remain inside a 32 em long furnace. The catalyst formed (10 g) was placed in the middle of the reactor and heated to 380° C. by means of an electric tube furnace. Acetaldehyde was added at a rate of 9.5 ml / hour and ammonia at a rate of 60 ml / minute. The product formed within 2 hours was condensed in an ice-cooled receiver, weighed, and analyzed by gas chro...

Embodiment 2

[0034] Catalyst preparation: Silica gel with a particle size of 6 to 14 mesh is used as a silicon-based carrier

[0035] Silicotungstic acid (10 g) was dissolved in water (25 ml), and the solution was mixed with silica gel (100 g). The slurry was stirred to obtain a homogeneous impregnation, dried in air at 225°C for 1 hour, then at 400°C for 1 hour, and finally cooled to room temperature in a desiccator. This catalyst is used for the reaction of acetaldehyde and ammonia.

[0036] The experiments were carried out in a downflow glass reactor with an inner diameter of 2 cm and sufficient length to remain inside a 32 cm long furnace. The catalyst formed (10 g) was placed in the middle of the reactor and heated to 400° C. by means of an electric tube furnace. Acetaldehyde was added at a rate of 9.5 ml / hour and ammonia at a rate of 60 ml / minute. The product formed within 2 hours was condensed in an ice-cooled receiver, weighed, and analyzed by gas chromatography (FID installed w...

Embodiment 3

[0037] Embodiment 3: the preparation of catalyst: particle size is that the silica gel of 6 to 14 mesh is used as silicon-based carrier

[0038] Vanadungstic acid (10 g) was dissolved in water (25 ml), and the solution was mixed with silica gel (100 g). The slurry was stirred to obtain a homogeneous impregnation, dried in air at 210°C for 1 hour, then at 400°C for 1 hour, and finally cooled to room temperature in a desiccator. This catalyst is used for the reaction of acetaldehyde and ammonia.

[0039] The experiments were carried out in a downflow glass reactor with an inner diameter of 2 cm and sufficient length to remain inside a 32 cm long furnace. The catalyst formed (10 g) was placed in the middle of the reactor and heated to 370° C. by means of an electric tube furnace. Acetaldehyde was added at a rate of 9.5 ml / hour and ammonia at a rate of 60 ml / minute. The product formed within 2 hours was condensed in an ice-cooled receiver, weighed, and analyzed by gas chromatog...

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Abstract

The present invention provides a catalyst comprising a composite of a heteropolyacid impregnated on a support for the synthesis of 2- and 4-picolines and a process for the preparation thereof and use thereof for the synthesis of 2- and 4-picolines.

Description

field of invention [0001] The invention provides a catalyst complex for synthesizing 2-picoline and 4-picoline. The invention also provides the preparation method of the catalyst for synthesizing 2-picoline and 4-picoline. The invention also provides a method for preparing 2-picoline and 4-picoline with the new catalyst. The present invention finds its use in the preparation of various intermediates for pharmaceuticals and agrochemicals. In the manufacture of pesticides, 2-picoline is one of the main components. The main use of 4-picoline is to synthesize 4-vinylpyridine and anti-tuberculosis drug, isoniazid (Iso-Nicotinic Acid Hydrazide) (INH). Background of the invention [0002] Important commercial sources of pyridine bases are tars and saturated solutions obtained by carbonization of coal. However, in pharmaceutical and agricultural applications, the high quality standards of these products cannot be met from natural sources, ie from the by-products of carbonization...

Claims

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Application Information

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IPC IPC(8): B01J27/188B01J27/199B01J21/04B01J21/06B01J21/08B01J21/12B01J21/16C07D213/10
CPCB01J21/16B01J21/08B01J21/04B01J27/199C07D213/10B01J21/12B01J23/002B01J2523/00B01J27/188B01J2523/41B01J2523/51B01J2523/69B01J2523/55
Inventor 帕舒帕蒂·杜塔苏巴什·钱德拉·罗伊希亚姆·基肖尔·罗伊塔伦·坎蒂·戈斯瓦米
Owner COUNCIL OF SCI & IND RES
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