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Composition of white mulberry leaf blood-sugar-reducing effective components and preparing method

A technology for effective components and compositions, which is applied in the directions of medical preparations, drug combinations, organic active components, etc. containing effective components, can solve problems such as no involvement, and achieve the effects of low cost, significant drug effect, and simple process.

Active Publication Date: 2006-10-25
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above patents do not relate to the preparation method of extracting mulberry leaf polysaccharide and alkaloid active ingredient composition from mulberry leaves, let alone the report on the combination of mulberry leaf polysaccharide and mulberry leaf alkaloid active ingredient for hypoglycemic purposes

Method used

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  • Composition of white mulberry leaf blood-sugar-reducing effective components and preparing method

Examples

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Effect test

preparation example

[0021] The preparation examples of mulberry leaf blood lipid-lowering effective component composition are as follows:

example 1

[0023] Take 2 kg of leaves of Moraceae mulberry, remove impurities, dry at low temperature, crush, add 3 times the volume of petroleum ether to extract, remove fat-soluble components, then filter, take slag and remove liquid. The organic solvent was evaporated from the filter residue to obtain mulberry powder residue. The mulberry powder residue is extracted by adding 5 times the volume of hot water, filtered, and the residue is removed to obtain the liquid. Add ethanol to the filtrate to make the concentration 40%, precipitate, and filter to obtain supernatant and precipitate. The supernatant was first purified with 001×8 (strongly acidic styrene-based cation exchange resin), eluted with 0.4M ammonia water, collected the eluate, concentrated, then purified with 701 (weak base 330 anion exchange resin), and washed with aqueous solution elute. The eluate is concentrated and dried to obtain mulberry leaf alkaloids, wherein the content of 1-Deoxynojirimycin (1-Deoxynojirimycin)...

example 2

[0025] Take 2 kg of leaves of the Moraceae plant mulberry, remove impurities, dry at low temperature, crush, add 5 times the volume of ethyl acetate to extract, remove fat-soluble components, then filter, take the residue and remove the liquid. The organic solvent was evaporated from the filter residue to obtain mulberry powder residue. The mulberry powder residue is extracted by adding 6 times the volume of hot water, filtered, and the residue is removed to obtain the liquid. Add ethanol to the filtrate to make the concentration 50%, precipitate, and filter to obtain supernatant and precipitate. The supernatant was first purified with D152 (macroporous weak acid acrylic cation exchange resin), eluted with 0.5M ammonia water, the eluate was collected and concentrated, and then purified with 201×4 (strongly basic styrene anion exchange resin). Elute with aqueous solution. The eluate is concentrated and dried to obtain mulberry leaf alkaloids, wherein the content of 1-Deoxynoj...

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Abstract

The present invention relates to a mulberry leaf effective component composition for reducing blood sugar and its preparation method. Said mulberry leaf effective component composition contains 20-80% of mulberry leaf polysaccharide and 80-20% of mulberry leaf alkaloid in which 1-deoxynojirimycin content is greater than 50%. Said preparation method includes the following steps: removing impurity, drying, pulverizing to obtain mulberry leaf powder, using organic solvent to make extraction, filtering, removing residue, using hot water to make extraction, filtering, adding ethyl alcohol into filtrate to make its concentration be 40%-80%, filtering to obtain supernatant fluid and precipitate, using cation exchange resin and anion exchange resin to make separation and remove impurity, concentrating and drying so as to obtain mulberry leaf alkaloid.

Description

technical field [0001] The invention relates to a mulberry leaf hypoglycemic active component composition and a preparation method, belonging to the field of traditional Chinese medicines. Background technique [0002] Planting mulberry and raising sericulture is one of the traditional agricultural industries in our country. Mulberry leaves have a lot of resource advantages in our country, but the traditional sericulture industry is only used for raising silkworms and has a single purpose. According to the normal situation, a large amount of mulberry leaves are surplus and wasted every year. Therefore, looking for multi-purpose development channels of mulberry leaves and developing them into medicines or health care products can not only make full use of natural resources, but also find new economic growth for the sericulture industry point to promote the development of the sericulture industry. [0003] And mulberry leaves are used in ancient Chinese medicine prescriptions...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/605A61K31/715A61K127/00A61P3/10C08B37/00
Inventor 欧阳臻贾晓斌李永辉常钰江涛涛
Owner JIANGSU UNIV
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