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Liver specificity ultra micro paramagnetism MRI centrast medium and its preparation method

A specific and paramagnetic technology, applied in the field of biomedical materials, can solve the problems of increasing the amount of contrast agent used, prone to adverse reactions, affecting the contrast effect, etc., to improve product safety, structural stability, and good biological safety. Effect

Inactive Publication Date: 2006-08-30
EAST CHINA NORMAL UNIV
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Problems solved by technology

[0009] Current status and existing problems of MRI contrast agents: According to different magnetic centers, MRI contrast agents can be divided into 1) paramagnetic substances: characterized by small magnetic susceptibility, and the magnetism cannot be retained without an external magnetic field
[0015] However, the reticuloendothelial system-specific contrast agents are all coated with biomacromolecules (mainly dextran), so the electromagnetic properties of the particles have also changed, and the magnetic responsiveness has weakened, which affects the contrast effect. Increased the amount of contrast medium used, so adverse reactions are prone to occur
In addition, biomacromolecules with certain cytotoxicity also bring toxic and side effects, resulting in many adverse reactions. For example, taking Feridex as an example, the incidence of mild side effects is 10% to 15%, among which low back pain is more common, and the incidence is about 3-4%, other side effects include flushing, rash and dyspnea

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  • Liver specificity ultra micro paramagnetism MRI centrast medium and its preparation method
  • Liver specificity ultra micro paramagnetism MRI centrast medium and its preparation method
  • Liver specificity ultra micro paramagnetism MRI centrast medium and its preparation method

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Embodiment Construction

[0055] Preparation method of liver-specific ultra-ultraminiature paramagnetic MRI contrast agent: Weigh FeCl 3 and FeCl 2 Dissolved in 2M hydrochloric acid, the final concentrations were 1M and 2M. Mix the two evenly according to a certain ratio, add an appropriate amount of betaine organic small molecule surfactant, and shake for 3 minutes to dissolve. Then slowly add 3M NaOH dropwise until the pH reaches about 11, and shake vigorously for 5 minutes to form iron oxide nanoparticles uniformly. Then slowly add 2M HCl dropwise until the pH reaches about 4, and continue to shake for 5 minutes, so that the small organic molecules of betaine can fully coat the iron oxide particles. The resulting black precipitate was separated by a permanent magnet, the supernatant and non-magnetic substances were removed, and the precipitate was dissolved with 6ml of distilled water. After the solution was centrifuged at 3500rpm for 5min, all other impurities including small molecular salts and...

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Abstract

A liver-specific superfine paramagnetc MRI contrast medium is prepared from the organic macromoleculae of betaine and superfine iron oxide particles. Its advantages are small diameter (4.6+ / -0.96 nm), high biologic safety, and strong atonicity and magnetic response.

Description

technical field [0001] The invention relates to a liver-specific ultra-ultraminiature paramagnetic MRI contrast agent, provides a preparation method of the contrast agent, and belongs to the technical field of biomedical materials. Background technique [0002] Magnetic resonance imaging (MRI) is one of the most important advances in medical imaging in the twentieth century, and it is also the most advanced large-scale medical diagnostic equipment in the world. One of its most prominent features in medical diagnosis is the clear imaging of soft tissues. In 1946, Purcell of Harvard University in the United States and Block of Stanford University in the United States independently discovered the phenomenon of nuclear magnetic resonance at the same time, and they were awarded the Nobel Prize in Physics in 1952. In 1971, engineering physicist Damadian discovered the longitudinal relaxation time (T 1 ), the transverse relaxation time (T 2 ) value is long...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/06
Inventor 赖立辉陈建照张鸿明戚艳婷
Owner EAST CHINA NORMAL UNIV
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