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Silicon microchannel array erythrocyte rheological analyzing method and apparatus

A technology of silicon microchannel and analysis method, which is applied in the field of measuring the deformability of red blood cells, can solve the problems such as the inability to observe the deformation of red blood cells in real time, and achieve the effects of flexible channel shape and size, convenient collection and analysis, and channel shape and size design

Inactive Publication Date: 2006-08-02
CHONGQING UNIV
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Problems solved by technology

This method also cannot observe the deformation of red blood cells in real time.
[0007] In short, the methods used to observe the deformability of red blood cells have yet to be perfected. There is no method that can directly observe the deformation process of red blood cells through a simple microscopic imaging system, and at the same time provide parameters of individual and group red blood cell deformation. Diagnostics provide richer rheological information

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  • Silicon microchannel array erythrocyte rheological analyzing method and apparatus
  • Silicon microchannel array erythrocyte rheological analyzing method and apparatus
  • Silicon microchannel array erythrocyte rheological analyzing method and apparatus

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Embodiment Construction

[0022] The following describes in detail the specific device and the specific process of the method for implementing the present invention in combination with each schematic diagram:

[0023] figure 1 It is a partial schematic diagram of the microchannel array chip 7. Its rectangular channel is indicated by A in the figure. Its width is 5um, depth is 5.2um, and length is 30um. It adopts MEMS processing technology and simulates the capillary network according to the requirements of red blood cell deformability detection. , Etched on silicon wafers.

[0024] in figure 2 In Figure A, the metallurgical microscope 9 is connected to the CCD camera 10 through the optical interface, the CCD camera is connected to the video capture card 13 through the video output line, and the CCD camera 10 captures the image data of the red blood cell through hole deformation process through the metallurgical microscope 9 through the video The capture card 13 is input to the computer 14 for image arch...

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Abstract

The present invention provides a red blood cell deformability analysis method based on silicon microchannel array chip and its equipment for implementing said method. Said equipment includes the following several portions: microchannel array chip closed in base seat, flow path control system containing speed detector, pressure pump and pressure sensor, computer and its interface, microscope and image collecting device. Said invention also provides the concrete connection relationship of all the above-mention portions and its working principle. Besides, said invention also provides the concrete steps of said analysis method.

Description

Technical field [0001] The invention belongs to the field of blood testing and analysis, and specifically relates to a method and a device for determining the deformability of red blood cells. Background technique [0002] At present, there are mainly the following technologies for measuring the deformability of red blood cells in the world: [0003] 1. The micropipette method is to measure the length of the red blood cells sucked by the micropipette under a constant negative pressure to determine the mechanical properties and deformation properties of the red blood cells. Since this method only measures a single red blood cell, the operation is complicated and time-consuming, so it is not suitable for promotion. [0004] 2. Laser diffraction method: Put the blood sample into the flow chamber. The red blood cell deforms due to the tangential stress. During the deformation, the laser intensity and the aspect ratio of the red blood cell are measured to de...

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Application Information

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IPC IPC(8): G01N33/49
Inventor 郑小林张文献彭承琳杨军侯文生王炼姜海翁璇
Owner CHONGQING UNIV
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