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Production of high-purity medicine with lamp-dish flower acetic as raw material

A technology for scutellarin and a preparation process, which is applied in the field of preparation technology of raw materials, can solve the problems of improving the purity of unreported scutellarin and eliminating side effects, achieves easy industrial production, solves instability, and solves problems in the process. simple steps

Active Publication Date: 2006-05-31
KUNMING LONGJIN PHARMA
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  • Abstract
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Problems solved by technology

There is no report on the refining process of scutellarin in the relevant literature and patent materials, and there is no report on the improvement of the purity of scutellarin and the elimination of side effects

Method used

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  • Production of high-purity medicine with lamp-dish flower acetic as raw material

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Embodiment

[0022] Weigh 1000g of commercially available breviscapine crude drug, add 10 times the weight of water, adjust the pH value to 7 with 30% sodium hydroxide solution, completely dissolve, filter, and add 8 times of acetone to the filtrate at 25°C for precipitation, while adding Stir while stirring to make the precipitation complete, let stand for 12 hours, filter, add acetone to wash three times, then move the precipitate to another container, add 6 times the amount of 40% acetone, stir well, then add 25% hydrochloric acid to adjust the acidity to PH1-2, let stand for 10 hours, filter with suction, wash with water until neutral, wash once with ethanol, and dry to obtain refined scutellarin. The content of scutellarin by HPLC analysis is 99.6892%, as shown in the attached figure .

[0023] Detection method: chromatographic conditions and system suitability test (using octadecyl bonded silica gel as filler: methanol-0.1% phosphoric acid solution (40:60) as mobile phase; detection ...

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Abstract

Process of high-purity breviscapine medicinal material includes laying breviscapine in container, adding into 2 time water, adding into alkaline solution, regulating pH 4-8, dissolving to obtain the alkaline solution which is one or several of sodium carbonate, potassium carbonate, sodium bicarbonate, potassium acid carbonate, sodium hydrate and potassium hydrate, adding into 3 time solvent, depositing at 18-35íÒC, laying aside, filtering, washing the deposit by solvent, transferring the deposit to solution with 10-60wt% solvent, acidizing to pH 1-2, depositing, filtering, washing to neutral, and drying to obtain the final product.

Description

technical field [0001] The invention relates to a preparation process of a bulk drug in the pharmaceutical industry, in particular to a preparation process of a high-purity bulk drug. Background technique [0002] Erigeron breviscapus (Vant.) Hand-Mazz is a flavonoid active ingredient isolated from the whole herb of Erigeron breviscapus (Vant.) Hand-Mazz, mainly scutellarin (also known as breviscapus, scutellarin, hereinafter referred to as B) , the chemical name is 4′5,6-trihydroxyflavone-7-O-glucuronide. The breviscapine raw material drug purchased from the market is analyzed by HPLC, and the content of B is about 90%. This preparation has been widely used clinically to treat cardiovascular and cerebrovascular diseases, and its curative effect is remarkable. However, its injection has poor stability and short storage time. Clinically, individual patients may experience cold and heat reactions, skin itching, and rashes after use. The appearance of the phenomenon is mainly ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/06
Inventor 张人伟程惠佳樊献俄
Owner KUNMING LONGJIN PHARMA
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