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Arrangement and method for the spatially resolved determination of state variables in an examination area

A detection area and detection object technology, applied in the field of magnetic particle composites and optical contrast composites, can solve problems such as insufficient, and achieve the effect of low saturation induction

Active Publication Date: 2006-05-17
KONINKLIJKE PHILIPS ELECTRONICS NV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although optical tomography methods such as optical scatter tomography have the advantage of very gentle and non-destructive detection of biological tissue, this method can only provide reliable data in the range of a small penetration depth of the detection object
Also, essentially two-dimensional imaging is often not sufficient

Method used

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  • Arrangement and method for the spatially resolved determination of state variables in an examination area

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Embodiment Construction

[0065] In this test setup, the test object 1 is located in a gradient magnetic field 2 which has a region 4 (first subregion) of low magnetic field strength around a magnetic field-free point 6, the magnetic field strength of which is so low Such that the magnetization of the magnetic particles located therein is not saturated, said region 4 is indicated by a dotted line. The magnetic particles present in the detection object 1 are not shown. Outside the weak magnetic field region 4, the magnetic particles are in a saturated state (second subregion 8). The size of the subfields 4 which determine the spatial resolution of the device depends on the one hand on the strength of the gradient magnetic field and on the other hand on the size of the magnetic field required for saturation. A suitable magnetic field can be generated using, for example, a pair of Maxwell coils 10 .

[0066] In the detection region, a further magnetic field oscillating or rotating in at least one spatia...

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Abstract

The present invention relates to a method for spatial resolution determination of mechanical, physical, chemical and / or biological properties or state variables in a detection area of ​​a detection object, and / or mechanical, chemical and / or biological properties or state variables in the detection area. The method includes the following steps: a) introducing magnetic particles into the detection area; b) generating a magnetic field, which includes a first magnetic field with a low magnetic field intensity. subdomain and a second subdomain with a higher magnetic field strength; c) generating a superimposed oscillating or rotating magnetic field in the first subdomain, causing at least some of these magnetic particles to oscillate or rotate; d) detecting the irradiating the area with electromagnetic radiation; and e) detecting the reflected and / or scattered electromagnetic radiation and determining the intensity, absorptivity and / or polarizability. The invention also relates to a device for implementing the method. The invention further relates to an optical contrast composition and a magnetic particle composition having improved imaging properties.

Description

technical field [0001] The invention relates to a device for spatially resolved determination of mechanical, physical, chemical and / or biological properties and state variables and changes in these properties and state variables within a detection region of a test object. The invention also relates to a method for spatially resolved determination of said properties and state variables using said device of the invention. The invention also relates to a magnetic particle composition and an optical contrast composition having improved magnetic particle imaging properties. . Background technique [0002] In the diagnosis of tumors such as breast cancer, radiographic imaging methods are often used, although a destructive effect on the irradiated tissue cannot be definitively ruled out. Nuclear spin tomography, ultrasound methods, and expensive and complex infrared tomography are also valid alternative detection methods. A particularly gentle examination of tissue is then possi...

Claims

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Application Information

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IPC IPC(8): A61B5/00A61B5/05A61B5/06A61K49/18
CPCA61B5/05A61B5/0515A61K49/0002A61K49/001A61K49/1818
Inventor B·格莱奇
Owner KONINKLIJKE PHILIPS ELECTRONICS NV
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