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Method for preparing medicine composition contg. aspirin

A technology for aspirin and composition, applied in the field of composition preparation, can solve the problems of unstable aspirin, gastrointestinal tract irritation, restricted application and the like

Inactive Publication Date: 2006-03-29
BEIJING YUEKANGKECHUANG PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The drug is an extremely valuable drug for the prevention and treatment of ischemic cerebrovascular diseases, such as transient ischemic attack, cerebral ischemic stroke, and cerebral arteriosclerosis, but unfortunately, aspirin is extremely unstable, and the general preparation When the method is preparing the pharmaceutical composition, or when the medicine is stored, it often inevitably causes a large amount of degradation of aspirin
And its degradation product, salicylic acid, has strong gastrointestinal irritation, which is not conducive to the use of patients, and thus greatly limits the application of the drug.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] prescription:

[0017] Material name

Dosage (g)

aspirin

Vitamin B 1

Microcrystalline Cellulose PH101

lactose

citric acid

2% hypromellose in water

20

10

10

34

1

about 20

[0018] Material name

Dosage (g)

Sodium Ferulate

Cinnarizine

Microcrystalline Cellulose PH101

lactose

2% hypromellose in water

50

25

25

50

about 40

[0019] Preparation:

[0020] 1. Sodium ferulate, aspirin, cinnarizine, lactose, and citric acid were respectively crushed through a 100-mesh sieve, vitamin B 1 Pass through a 100-mesh sieve, and microcrystalline cellulose pass through a 80-mesh sieve, and set aside.

[0021] 2. Prepare 2% hypromellose aqueous solution as a binder respectively, and set aside.

[0022] 3. According to aspirin and vitamin B 1 The ratio of some prescription components, weigh aspirin and vitamin B respectively 1 , micr...

Embodiment 2

[0032] prescription:

[0033] Material name

Dosage (g)

aspirin

Vitamin B 1

Microcrystalline Cellulose PH101

lactose

citric acid

2% hypromellose in water

20

10

10

34

1

about 20

[0034] Material name

Dosage (g)

Sodium Ferulate

Cinnarizine

Microcrystalline Cellulose PH101

lactose

2% hypromellose in water

50

25

25

50

about 40

[0035] Preparation:

[0036] 1. Sodium ferulate, aspirin, cinnarizine, lactose, and citric acid were respectively crushed through a 100-mesh sieve, vitamin B 1 Pass through a 100-mesh sieve, and microcrystalline cellulose pass through a 80-mesh sieve, and set aside.

[0037] 2. Prepare 2% hypromellose aqueous solution as a binder respectively, and set aside.

[0038] 3. According to aspirin and vitamin B 1 The ratio of some prescription components, weigh aspirin and vitamin B respectively 1 , micr...

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PUM

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Abstract

A process for preparing a compound containing aspirin to improve the stability of aspirin includes such steps as proportionally mixing aspirin, VB1 and auxiliary, pilling or granulating, proportionally mixing sodium ferulate with cinnarizine, pilling or granulating, mixing the prepared pills or particles loading in capsules or tabletting.

Description

Technical field: [0001] The invention relates to a preparation method of a composition, which contains aspirin, sodium ferulate, cinnarizine and vitamin B 1 Four ingredients. The invention is characterized in that by combining aspirin with vitamin B 1 Make pellets or granules together with appropriate amount of auxiliary materials, sodium ferulate and cinnarizine together with appropriate amount of auxiliary materials to make pellets or granules, then mix the two kinds of pills or granules in proportion and then pack them into capsules, or mix the two kinds of pills or granules by pressing Proportional layered tablet compression significantly improves the stability of aspirin. Background technique: [0002] The composition involved in the present invention contains aspirin, sodium ferulate, cinnarizine and vitamin B 1 Four ingredients. [0003] At present, this product is widely used in the prevention and treatment of ischemic cerebrovascular diseases, such as transient ...

Claims

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Application Information

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IPC IPC(8): A61K31/616A61K9/48A61P9/10A61K31/192A61K31/51A61K31/495
Inventor 马希正李艳友
Owner BEIJING YUEKANGKECHUANG PHARM TECH CO LTD
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