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Compound medicine granulaes for treating entroendotoxinemia and preparing method

An endotoxemia and compound technology, applied in drug combination, antibacterial drugs, blood diseases, etc., can solve the problem of untimely intervention of endotoxemia, high incidence of endotoxemia, and human harm of endotoxemia, etc. To achieve the effect of increasing the ileal contraction strength in vivo, taking less dosage, and inhibiting tumor necrosis factor

Inactive Publication Date: 2006-03-08
YANGTZE RIVER PHARM GRP CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] (3) High incidence of endotoxemia
[0008] (5), endotoxemia is extensive and serious to the human body
[0009] (6), for endotoxemia, there is no effective prevention and treatment measures
[0010] (7) If the intervention of endotoxemia is not timely, the prognosis will be worse
However, most of the above-mentioned anti-endotoxin preparations are still in the stage of experimental research, and most of the drugs put into clinical use are expensive, so their application has certain limitations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0034] Take 1.7 kg of rhubarb, add 15 times the amount of boiling water, reboil and decoct three times, 20 minutes each time, combine the decoction, centrifuge, all the supernatant passes through the macroporous adsorption resin column, control the flow rate to 1 times the column volume / hour, and then add Rinse with 1 times the column volume of water, then elute with 1 times the column volume of 70% ethanol, control the flow rate to 0.5 times the column volume / hour, then wash with 1 times the column volume of water, collect the eluate, and recover ethanol under reduced pressure Concentrate to a relative density of about 1.04 for later use. Take 1.3 kg of Citrus aurantium and 1.3 kg of Magnolia officinalis, add 8 times the amount of 50% ethanol for reflux extraction three times, each time for 1 hour, filter, combine the filtrate, recover the ethanol under reduced pressure until the relative density is about 1.11, add 0.3 kg of Glauber's salt Carry out vacuum drying with appropr...

preparation example 2

[0036] Take 1.0 kg of rhubarb, add 10 times the amount of boiling water, reboil and decoct three times, 20 minutes each time, combine the decoction, centrifuge, all the supernatant passes through the macroporous adsorption resin column, control the flow rate to 1 times the column volume / hour, and then add Rinse with 1 times the column volume of water, then elute with 1.2 times the column volume of 85% ethanol, control the flow rate to 0.7 times the column volume / hour, then wash with 1 times the column volume of water, collect the eluate, and recover ethanol under reduced pressure Concentrate to a relative density of about 1.10 for later use. Take 0.5 kg of Citrus aurantium and 0.5 kg of Magnolia officinalis, add 10 times the amount of 70% ethanol for reflux extraction three times, each time for 1 hour, filter, combine the filtrate, recover the ethanol under reduced pressure to a relative density of about 1.15, add 0.15 kg of Glauber's salt Carry out vacuum drying with appropri...

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PUM

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Abstract

The present invention relates to a compound medicine granule preparation for effectively curing entero toxemia and its preparation method. Its composition includes the following main components: rhubarb 0.1-10kg, bitter orange 0.1-8kg, magnolia bark 0.1-8kg and mirabilite 0.01-3kg. Said invention also provides the concrete steps of its preparation method.

Description

Technical field: [0001] The invention relates to a compound medicine granule for treating intestinal-derived endotoxemia and a preparation method thereof. Background technique: [0002] Modern medicine believes that detectable endotoxins appear in circulating blood, which is called endotoxemia. Among them, those without gram-negative bacteria (gram-negative bacteria, G-bacteria) infection are called intestinal endotoxemia (intestinal endotoxemia, IETM), which has the following characteristics: [0003] (1) Detectable endotoxins in circulating blood without Gram-negative bacterial infection belong to enterogenous endotoxemia. [0004] (2) After endotoxin is absorbed from the colon, it enters the blood circulation through at least two pathways: mesenteric vein-portal vein and intraperitoneal lymphatic vessel-thoracic duct. Endotoxin absorption increases in inflammatory or ischemic bowel disease. [0005] The intestinal tract is the largest bacterial bank and endotoxin pool i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/75A61K36/708A61K36/57A61K33/04A61K9/16A61P31/04A61P7/00A61P43/00
Inventor 吴咸中伍孝先蔡伟金波李薇
Owner YANGTZE RIVER PHARM GRP CO LTD
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