Cefuroxime sodium and sulbactam sodium composition for injection

Abstract

The invention provides a composition of cefuroxime sodium and sulbactam sodium for injection, which comprises cefuroxime sodium and sulbactam sodium by the weight ratio of 15:1. The composition has good antibiotic action and low cost of production.

Description

technical field [0001] The invention relates to an antibacterial drug composition, which is an anti-β-lactamase antibiotic compound preparation. Background technique [0002] Cefuroxime (CXM) is a second-generation cephalosporin. As a broad-spectrum bactericidal antibiotic, it has strong antibacterial effect on Gram-positive bacteria and most Gram-negative bacteria. , Low nephrotoxicity. With the widespread clinical use of cefuroxime, some strains that were originally sensitive to cefuroxime developed resistance to cefuroxime, making its antibacterial effect decline. Studies have found that the main mechanism of bacterial resistance to cephalosporins is to produce specific β-lactamase to decompose drugs. [0003] In order to overcome the drug resistance caused by β-lactamase-producing bacteria, people began to develop an anti-β-lactamase antibiotic compound preparation composed of cefuroxime and sulbactam, and achieved certain results. Tests showed that this compound In v...

AI Technical Summary

Problems solved by technology

[0004] Although the composition of cefuroxime and its salts and sulbactam or its salts has ideal antibacterial and bactericidal effects on enzyme-producing strains in vitro, due to the high price of sulbactam and its sodium salts, this composition is made The high cost of preparations of this kind of medicine makes it difficult for some patients, especially those in economically backward poverty-stricken areas or families with financial difficulties, to accept or bear it, which limits the use and exertion of this kind of medicine. The role of these patients also makes it impossible for these patients to receive timely and effective treatment.