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Eucalyptus extracts

An extract, eucalyptus technology, applied in the field of plant extracts, can solve the problem of not being able to add

Active Publication Date: 2006-02-01
KAO CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, when used in cosmetics, pharmaceuticals, quasi-drugs, etc., it cannot be added in a sufficient amount to show its effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

manufacture example

[0026] Production example Preparation of eucalyptus extract

[0027] (Process 1)

[0028] 100 g of dried eucalyptus leaves were crushed, 1000 mL of 50 volume % ethanol aqueous solution was added, extraction was carried out at room temperature for 7 days, and then filtered to obtain 880 mL of eucalyptus extract.

[0029] Evaporation residue: 3.62w / v%

[0030] 1,8-Cineole: 0.2% by weight

[0031] Cypress A: 0.018% by weight

[0032] (1,8-Cineole / Cypress A=11 / 1)

[0033] Evaluation of odor: A fairly strong odor peculiar to eucalyptus was emitted.

[0034] (Process 2)

[0035] The solvent in 100 mL of the above eucalyptus extract was distilled off under reduced pressure, and further dried under reduced pressure to obtain 4 g of eucalyptus extract.

[0036] 1,8-Cineole: 0.25% by weight

[0037] Cypress A: 0.45% by weight

[0038] (1,8-Cineole / Cypress A=1 / 1.8)

[0039] Evaluation of odor: A slight odor peculiar to eucalyptus was emitted.

[0040] (Process 3)

[0041] 4 g ...

Embodiment 1

[0046] Example 1 Effect of Promoting Ceramide Production

[0047] method

[0048] Using a 6-well plate, containing [ 14 C]-serine (manufactured by Daiichi Chemical Co., Ltd.) culture medium (GIBCO SFM / -BPE, EGF), human keratinocytes (HK-f; manufactured by Kukuto Pharmaceutical Co., Ltd.) at 37 ° C, 5% CO 2Incubate for 24 hours. Then, 0.001% by weight of the eucalyptus extract obtained in Production Example 1 was added in terms of solid content, and further cultured for 24 hours. After removing the culture medium and washing once in PBS, the cells were scraped with a cell scraper and collected in a test tube. After adding 3.6 mL of water, 4 mL of chloroform, and 4 mL of methanol to the human keratinocytes and mixing, the chloroform layer was isolated and dried to solidify. The extracted lipid was developed to the top twice with solvent 1 (chloroform:methanol:acetic acid=190:9:1) on an HPTLC plate [silica gel G60 (20×10cm) Art.5641; manufactured by Melc], and further Solven...

Embodiment 2

[0051] Example 2 Hair Quality Improvement Effect

[0052] Hair quality improvement effects such as softness, tension, elasticity, etc. were evaluated by measuring the bending elastic modulus of woodchuck body hair.

[0053] method

[0054] The body hair of the central part of the back of four groundhogs was shaved, and the central part of the back of the same individual was divided into two regions, the left and the right. A diluted solution of 0.0001% by weight of the eucalyptus extract obtained in the production example and a solvent containing no eucalyptus extract as a control were applied to these two areas, respectively. After 4 weeks, 30 pieces of body hair (about 20 mm in length and about 50 μm in thickness) were cut from the left and right regions to measure the bending elastic modulus. Two stainless steel plates with a length of 40 mm, a width of 15 mm, and a thickness of 0.3 mm were placed at an interval of 5 mm, and 30 body hairs were attached at an interval of 1...

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Abstract

The present invention provides a eucalyptus extract suitable for applications for a cosmetic, a medicine and an unregulated drug having reduced smell peculiar to the eucalyptus. The eucalyptus extract contains macrocarpal A and is regulated so that the ratio (1,8-cineole / macrocarpal A) of 1,8-cineole to the macrocarpal A by weight in the extract may be >=0 and <=1.0.

Description

technical field [0001] The invention relates to a plant extract used in the fields of external medicines, medicines, cosmetics and the like. Background technique [0002] It has been reported that in addition to antibacterial and anti-inflammatory effects, eucalyptus extract also has the effect of promoting the production of ceramide (Japanese Patent Application Publication No. 2000-169259) and hair quality improving agent (Japanese Patent Application Publication No. 2001-270811), etc. Effect. However, eucalyptus extract has a characteristic odor. Its odor is so strong that it can be felt even with a small amount of extract. Therefore, when used in cosmetics, pharmaceuticals, quasi-drugs, and the like, it cannot be added in a sufficient amount to exhibit the effect. Contents of the invention [0003] The invention provides a eucalyptus extract which is suitable for cosmetics, medicines, external medicines and the like, and which reduces the peculiar smell of eucalyptus....

Claims

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Application Information

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IPC IPC(8): A61K8/97A61Q5/00A61K31/11A61K31/352A61P17/16
Inventor 楠奥比吕志
Owner KAO CORP
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