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Compound analgesic agent

A cataplasm and compound technology, applied in the field of medicine, can solve problems that have not yet been seen, and achieve good therapeutic effects

Inactive Publication Date: 2005-10-12
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there have been some reports on the transdermal absorption of Panax notoginseng for external use, including transdermal absorption of Panax notoginseng powder [Cai Qingshun et al. Research on transdermal absorption of Panax notoginseng powder. Journal of Jiangxi University of Traditional Chinese Medicine, 2002; 14(4): 9-10] , the development of Panax notoginseng cataplasm [Yi Jun et al. Selection of transdermal absorption accelerators in Sanqi cataplasm. Journal of Guangdong Pharmaceutical University, 2000; 16(2): 91-93], etc., but they are all traditional Chinese medicines Compound preparations, there is no Chinese and Western medicine compound cataplasm product composed of Sanqi and lidocaine hydrochloride or related reports

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1 compound analgesic cataplasm

[0013] Formula and ratio:

[0014] Lidocaine hydrochloride 2.5g Panax notoginseng superfine powder 3g

[0015] Gelatin 1g Sodium Carboxymethyl Cellulose 2g

[0016] Polyvinylpyrrolidone K90 3g Sorbitol 19g

[0017] Polyacrylic acid NP700 1g Kaolin 5g

[0018] Propylene Glycol 10g Glycerin 5g

[0019] Ethanol 5g Ethylparaben 0.08g

[0020] Edetate Disodium 0.04g Calcium Hydroxide 0.25g

[0021] Tartaric acid 0.125g Purified water 30ml

[0022] The preparation method is:

[0023] 1. Prepare (I) phase solution: fully swell the gelatin with water according to the above ratio, dissolve it in a water bath at 60°C, add sorbitol, edetate disodium, calcium hydroxide, kaolin, lidocaine hydrochloride and Panax notoginseng superfine Add the powder into the gelatin, fully stir and dissolve to obtain the (I) phase solution;

[0024] 2. Dissolve ethylparaben in propylene glycol, add gl...

Embodiment 2

[0026] Embodiment 2 compound analgesic cataplasm

[0027] Formula and ratio:

[0028] Lidocaine hydrochloride 5g Panax notoginseng ethanol extract 0.6g

[0029] Gelatin 1g Sodium Carboxymethyl Cellulose 2g

[0030] Polyvinylpyrrolidone K90 3g Sorbitol 19g

[0031] Polyacrylic acid NP700 2g Kaolin 5g

[0032] Propylene Glycol 10g Glycerin 5g

[0033] Ethanol 5g Ethylparaben 0.08g

[0034] Edetate Disodium 0.04g Calcium Hydroxide 0.4g

[0035] Citric acid 0.2g Methyl salicylate 2.0g

[0036] Purified water 30ml

[0037] The preparation method is:

[0038] 1. Prepare (I) phase solution: fully swell the gelatin with water according to the above ratio, dissolve it in a water bath at 60°C, extract sorbitol, edetate disodium, calcium hydroxide, kaolin, lidocaine hydrochloride and notoginseng ethanol Thing is added in the gelatin, fully stirs, dissolves, obtains (I) phase solution;

[0039] 2. Dissolve ethylparaben in pro...

Embodiment 3

[0041] Embodiment 3 compound analgesic cataplasm

[0042] Formula and ratio:

[0043] Lidocaine hydrochloride 2.5g Panax notoginseng superfine powder 5g

[0044] Gelatin 2g Sodium Carboxymethyl Cellulose 2g

[0045] Polyvinylpyrrolidone K30 2g Sorbitol 19g

[0046] Polyacrylic acid NP600 2g Kaolin 5g

[0047] Propylene Glycol 10g Glycerin 5g

[0048] Ethanol 5g Methylparaben 0.08g

[0049] Edetate Disodium 0.04g Calcium Hydroxide 0.4g

[0050] Citric acid 0.2g Menthol 2.0g

[0051] Purified water 30ml

[0052] The preparation method is:

[0053] 1. Prepare (I) phase solution: fully swell the gelatin with water according to the above ratio, dissolve it in a water bath at 60°C, add sorbitol, edetate disodium, calcium hydroxide, kaolin, lidocaine hydrochloride and Panax notoginseng superfine Add the powder into the gelatin, fully stir and dissolve to obtain the (I) phase solution;

[0054] 2. Dissolve methylparaben a...

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Abstract

A compound analgesic for bone fracture, injury, ecchymoma, nerval pain, etc is composed of antisticking layer, hydrophilic gel layer and substrate layer. Said hydrophilic gel layer consists of the medicine prepared from lidocaine hydrochloride and superfine notoginseng powder or its extract and the matrix prepared from gelatin, carboxymethyl cellulose sodium, polyvinyl pyrrolidone, etc.

Description

Technical field: [0001] The invention relates to the technical field of medicine, and relates to an analgesic cataplasm prepared from a compound prescription of lidocaine hydrochloride and notoginseng. Background technique: [0002] Lidocaine hydrochloride is a commonly used amide-type medium-effect local anesthetic in clinical practice. It has the advantages of fast and strong local anesthetic effect, strong penetrating power and long effect, and is considered to be an ideal local anesthetic. At present, the 5% lidocaine patch for skin administration has been approved to go on the market (trade name LIDODERM) abroad.  ), has the characteristics of low systemic blood drug concentration, drug concentration at the site of administration, and less systemic adverse reactions. It is widely used for pain relief of peripheral neuralgia, especially post-herpetic neuropathic pain. There are also some domestic research reports on the transdermal absorption of lidocaine [Cheng Yuhui ...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61P25/04A61P29/00
Inventor 朱全刚胡晋红刘继勇孙华君
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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