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Quick dissolving solid injection of yew alkyl group, preparation method and application

A technology of taxanes and injections, which is applied in the field of medicine, can solve the problems that taxanes and hyaluronic acid solid injections have no reports on the application of immunomodulatory drugs, and achieve the effect of improving immunity

Inactive Publication Date: 2005-08-31
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, taxane and hyaluronic acid are made into instant solid injection, the preparation method of taxane and hyaluronic acid solid injection and the application of this solid injection in the preparation of immunomodulatory drugs are not yet reported.

Method used

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  • Quick dissolving solid injection of yew alkyl group, preparation method and application
  • Quick dissolving solid injection of yew alkyl group, preparation method and application
  • Quick dissolving solid injection of yew alkyl group, preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] (1) Each component is calculated by weight:

[0040] Paclitaxel: 0.2g

[0041] Ethanol: 0.2g

[0042] Hyaluronic acid: 10.5g

[0043] Glucose: 11.1g

[0044] Propylene glycol: 26g

[0045] Polyoxyethylene castor oil: 52g

[0046] (2) Dissolve paclitaxel in ethanol, then add polyoxyethylene castor oil to make solution one; add propylene glycol to hyaluronic acid, and add ultrapure water to make the hyaluronic acid aqueous solution have a concentration of 0.1% by weight. Aqueous solution, then add mannitol to make solution two, add solution two slowly to solution one under stirring, then mix the solution evenly with a milk homogenizer, remove the ethanol in vacuum, and use freeze drying or spray drying to make purple Fast-dissolving solid injection of taxanes. (Ethanol can be added by volume by conversion).

Embodiment 2

[0048] (1) Each component is calculated by weight:

[0049] Docetaxel: 0.5g

[0050] Ethanol: 0.5g

[0051] Hyaluronic acid: 2.5g

[0052] Glucose: 23.5g

[0053] Propylene glycol: 26g

[0054] Polyoxyethylene castor oil: 47g

[0055] (2) Using the preparation process of Example 1, replacing paclitaxel with docetaxel, the other steps are the same as in Example 1, and the concentration of the hyaluronic acid aqueous solution is 0.25% by weight.

Embodiment 3

[0057] (1) Each component is calculated by weight:

[0058] Paclitaxel: 0.3g

[0059] Ethanol: 0.4g

[0060] Hyaluronic acid: 9g

[0061] Mannitol: 39.5g

[0062] Propylene glycol: 2.8g

[0063] Soil temperature-80: 48g

[0064] (2) Using the preparation process of Example 1, replace glucose with mannitol and polyoxyethylene castor oil with Tween-80. The other steps are the same as in Example 1, and the concentration of hyaluronic acid aqueous solution is 0.2% by weight.

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Abstract

An instant solid injection of taxane for improving immunity is prepared through preparing solution A from taxol or polyenyltaxol, polyoxyvinyl castor oil or tween-80 or glycol laurylhydroxy stearate, and alcohol, preparing solution B from propanediol, hyaluronic acid, high-purity water and mannitol or glucose, slurry adding the solution B to solution A while stirring, homogenizing while emulsifying vacuum removal of alcohol, and freeze (or spray) drying.

Description

Technical field [0001] The invention belongs to the field of medicine, and specifically relates to a taxane hyaluronic acid preparation, a preparation method and application in the preparation of immunomodulatory drugs. Background technique [0002] Currently, immune diseases have become one of the main factors that seriously threaten human health. Immune system damaging diseases such as AIDS and lupus erythematosus are diseases for which there is no specific treatment at present, and the mortality rate of their patients is extremely high. Tumor is a serious threat to human health and even life-threatening diseases. The mortality rate caused by malignant tumors ranks second in the incidence of various diseases after cardiovascular diseases. The immune system of cancer patients is often suppressed by tumor cells, resulting in a decrease in the patient’s autonomic immunity, susceptibility to various diseases and aggravation of the disease. Therefore, improving the autoimmune activi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K9/19A61K31/337A61P37/02
Inventor 元英进殷殿书葛志强
Owner TIANJIN UNIV
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