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Application of liganans of biphenyl cyelo-octadiene in preparing antineoplastic medicine

A technology of biphenyl cyclooctene lignans and lignans, which are applied in the directions of antitumor drugs, drug delivery, drug combination and the like

Inactive Publication Date: 2005-08-31
普尔药物科技开发(深圳)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the process of studying the lignans in Tiejuopan, our laboratory isolated the biphenylcyclooctadiene lignan compound Schisantherin I (Schisandra I), and so far no activity reports about this compound have been seen.

Method used

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  • Application of liganans of biphenyl cyelo-octadiene in preparing antineoplastic medicine
  • Application of liganans of biphenyl cyelo-octadiene in preparing antineoplastic medicine
  • Application of liganans of biphenyl cyelo-octadiene in preparing antineoplastic medicine

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Embodiment Construction

[0021] The examples listed below help those skilled in the art to better understand the present invention, but do not limit the present invention in any way.

[0022] The pharmaceutical composition of the present invention contains a physiologically effective amount of biphenylcyclooctene lignans and / or a pharmaceutically acceptable carrier, and the biphenylcyclooctene lignans I is 1-hydroxy-2,3 , 12,13,14-Pentamethoxy-6-hexanoate-7-hydroxy-8-methyl-9-benzoate-biphenylcyclooctadiene lignan.

[0023] The above-mentioned pharmaceutical composition can be applied to the preparation of drugs for treating and / or preventing tumors.

[0024] The above-mentioned biphenylcyclooctene lignan compounds can be applied to the preparation of drugs for treating and / or preventing tumors, and the biphenylcyclooctene compound is 1-hydroxy-2,3,12,13,14-pentamethoxy Benzyl-6-hexanoate-7-hydroxy-8-methyl-9-benzoate-biphenylcyclooctadiene lignan.

[0025] The pharmaceutical composition of the present in...

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Abstract

An application of 1-hydroxy-2,3,12,13,14-pentamethoxy-6- hexanoately-7-hydroxy-8-methyl-9-benzoately-biphenyl cyclooctadiene lignan, white is extracted from schisandra propinqua, in preparing antineoplastic medicines is disclosed.

Description

Technical field [0001] The present invention relates to the cytotoxicity of biphenylcyclooctadiene lignan compound I isolated from the roots and stems of Schisandra propinqua (Wall.) Baill.], a medicinal plant of the genus Schisandra, to hematoma and solid tumors Function, inducing apoptosis, influencing cell cycle and its application in the clinical prevention and treatment of tumors. Background technique [0002] Biphenylcyclooctadiene-like lignans are mainly derived from plants of the Schisandraceae family in nature, and are characteristic components of plants of this family. This type of lignans has a unique skeleton, complex stereochemistry and extensive biological activities. In the 1970s, my country's clinical research found that Schisandra can significantly reduce the serum glutamate transaminase SGPT level in patients with hepatitis, which caused a boom in the study of Schisandra medicinal plants, and the development of a hepatitis drug bifendate. In recent years, people...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/222A61P35/00
Inventor 陈新滋肖培根陈士林陈四保许利嘉
Owner 普尔药物科技开发(深圳)有限公司
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