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Palatable chewable tablet

A chewable tablet and tablet technology, which can be used in pill delivery, allergic diseases, drug combinations, etc., and can solve problems such as increasing the cost of tablet manufacturing

Inactive Publication Date: 2005-07-20
PFIZER PRODS ETAT DE CONNECTICUT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, coating requires an additional manufacturing step, which increases the manufacturing cost of the tablet

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0025] Cetirizine bilayer chewable tablet:

[0026] Bilayer chewable tablets were prepared using the following two formulations. Each formulation is prepared separately and then compressed on a bilayer tablet press.

[0027] Element

[0028] Element

[0029] * Available from Warner-Jenkinson, South Plainfields, NJ.

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PUM

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Abstract

A palatable chewable tablet is described herein for oral administration of cetirizine dihydrochloride. The formulation is made more palatable by incorporating a combination of a grape-flavoring agent with a vanilla flavoring agent.

Description

technical field [0001] The present invention relates to a chewable tablet, in particular to a chewable tablet which can provide a delicious taste to mask the bitterness in the medicament. Background technique [0002] Cetirizine is the common name for 2-[2-[4-[(4-chlorophenyl)benzyl]-1-piperazinyl]ethoxy]acetic acid, usually dihydrochloric acid Salt. Cetirizine is an orally active selective H1 receptor antagonist currently used for the treatment of seasonal allergies in patients 2 years of age or older. Commercial products currently used in pediatrics (Zyrtec TM ) a white, film-coated, oral tablet with immediate release concentrations of 5 and 10 mgA and the other as a sweetened syrup containing cetirizine hydrochloride at a concentration of 1 mg / ml. Formulations of cetirizine for controlled or sustained release of cetirizine in tablets and capsules are described in European Patent Nos. 058,146, 294,993 and 357,369, and WO 92 / 02212. Oral formulations in the form of cough...

Claims

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Application Information

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IPC IPC(8): C07D295/08A61K9/00A61K9/20A61K9/24A61K9/28A61K31/495A61K47/04A61K47/12A61K47/22A61K47/26A61K47/38A61K47/40A61K47/46
CPCA61K9/282A61K31/495A61K9/2086A61K9/2826A61K9/0056A61K9/209A61P37/08A61K9/20
Inventor 卡斯拉·卡斯雷安坦亚·哈夫利尔
Owner PFIZER PRODS ETAT DE CONNECTICUT
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