Vision acuity improving eye drop and its preparation

A technology of eye drops and pearl liquid, which is applied in the direction of medical formulas, unknown raw materials, medical preparations containing active ingredients, etc., can solve problems such as the loss of pearl eye drops and short residence time of drugs, and reduce irritation , increase the effect, increase the effect of residence time

Active Publication Date: 2005-07-06
苏州工业园区天龙制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, according to the current common prescription, it can be found that most o...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1: pearl eye drops for improving eyesight and its preparation

[0040] prescription

[0041] Pearl liquid 20ml (with total protein not less than 20mg)

[0042] Borneol 1.0g

[0043] Ethylparaben 0.5g

[0044] Sodium Hyaluronate 1.5g

[0045] Sodium chloride 8.9g

[0046] 95% ethanol 5ml

[0047] Add water for injection to 1000ml;

[0048] Preparation steps:

[0049] Preparation of pearl liquid: Weigh 500g of pearl powder and add it to 2000ml of water for injection, heat to 95-100°C, keep warm, stir to fully react for 2-3 hours, pour out the supernatant, and filter the supernatant through a 0.45μm membrane The pearl liquid was prepared, and the total protein content of the pearl liquid was determined to be 300 μg / ml.

[0050] Preparation of Pearl Eye Drops:

[0051] (1) Add appropriate amount of sodium chloride to distilled water, heat to boil, cool to 80 degrees Celsius, add pearl liquid, and cool to 60 degrees Celsius while adding;

[0052] (2) Dis...

Embodiment 2

[0054] Embodiment 2: Zhuzhu Mingmu eye drops and its preparation

[0055] prescription:

[0056] Pearl liquid 20ml

[0057] Borneol 1.0g

[0058] Ethylparaben 0.5g

[0059] Sodium Hyaluronate 1.0g

[0060] Sodium chloride 5.5g

[0061] 95% ethanol 5ml

[0062] Add water for injection to 1000ml;

[0063] Preparation steps:

[0064] Get the pearl liquid that embodiment 1 makes.

[0065] (1) Add appropriate amount of sodium chloride to distilled water, heat to boil, cool to 80 degrees Celsius, add pearl liquid, and cool to 60 degrees Celsius while adding;

[0066] (2) Dissolve borneol and ethylparaben in ethanol, add dropwise to the above solution while stirring, add water and stir for 40 minutes;

[0067] (2) Add the thickening agent sodium hyaluronate into the above solution, dissolve it completely, adjust the pH to 6.0, filter, pour to make 1000ml, pot and seal it.

Embodiment 3

[0068] Embodiment 3: pearl eye drops for improving eyesight

[0069] prescription:

[0070] Pearl liquid 20ml (with total protein not less than 20mg)

[0071] Borneol 1.0g

[0072] Ethylparaben 0.5g

[0073] Sodium Hyaluronate 1.2g

[0074] Sodium chloride 6.5g

[0075] 95% ethanol 5ml

[0076] Add water for injection to 1000ml

[0077] Preparation steps:

[0078] Get the pearl liquid that embodiment 1 makes.

[0079] (1) Add appropriate amount of sodium chloride to distilled water, heat to boil, cool to 80 degrees Celsius, add pearl liquid, and cool to 60 degrees Celsius while adding;

[0080] (2) Dissolve borneol and ethylparaben in ethanol, add dropwise to the above solution while stirring, add water and stir for 50 minutes;

[0081] (3) Add the thickening agent sodium hyaluronate into the above solution, dissolve it completely, adjust the pH to 7.5, filter, pour to make 1000ml, pot and seal it.

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PUM

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Abstract

The invention discloses a vision acuity improving eye drop and its preparation, wherein a kind of thickening agent is added into the formula of the preparation, which can increase the retention time of the medicament in eyes, reducing irritation action, and realizing the purpose of improving pharmaceutical curative effect without changing the production condition and equipment.

Description

(1) Technical field [0001] The invention relates to pearl eye drops for improving eyesight and a preparation method thereof. (2) Background technology [0002] Pearl Mingmu Eye Drops has the effects of clearing away heat and purging fire, nourishing the liver and improving eyesight, and reducing inflammation. It is mainly used for symptoms such as visual fatigue and chronic conjunctivitis, and is also used to improve eye swelling and itchy eyes. However, according to the current common prescription, it can be found that most of the pearl eye drops are lost after use, and the drug stays in the eye for a short time. (3) Contents of the invention [0003] The object of the present invention is to provide a kind of pearl eyesight drop (the main component pearl liquid includes the pearl of various origins), be equipped with thickening agent, make a kind of can increase the residence time of medicine in eye and reduce stimulation The new pearl eye drops (colloidal solution). ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K35/618A61P27/02
Inventor 郑樑元陈坚
Owner 苏州工业园区天龙制药有限公司
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