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Application of alpha cyclo-alanine in the process for preparing medicine to treat cerebrovascular and cardiovascular disease

A technology for cardiovascular and cerebrovascular diseases and cycloalanine, which is applied in the application field of α-cycloalanine in the preparation of drugs for the treatment of cardiovascular and cerebrovascular diseases, achieving the effect of no toxic side effects and clear pharmacological effects

Inactive Publication Date: 2005-06-29
朱旭祥
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] α-Cycloalanine (1-aminocyclopropanecarboxylic acid, ACPC) is a natural non-protein special amino acid, which is currently mainly used to prepare poultry feed additives. It has been reported that α-Cyclopropanecarboxylic acid (ACPC) can be used to prepare drugs for the treatment of mental diseases , such as anxiety, depression, etc., there is no relevant report on the application of α-cycloalanine in the preparation of drugs for cardiovascular and cerebrovascular diseases

Method used

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  • Application of alpha cyclo-alanine in the process for preparing medicine to treat cerebrovascular and cardiovascular disease
  • Application of alpha cyclo-alanine in the process for preparing medicine to treat cerebrovascular and cardiovascular disease
  • Application of alpha cyclo-alanine in the process for preparing medicine to treat cerebrovascular and cardiovascular disease

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Experimental program
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Effect test

Embodiment 1

[0015] Embodiment 1: Pharmacological experiment of SHR-SP rats

[0016] (1) Model and method:

[0017] Twenty SHR-SP rats were divided into ACPC treatment group and control group, 10 in each group. The α-cycloalanine (ACPC) treatment group was injected intraperitoneally (iP) at a dose of 50 mg / kg (50 mg ACPC / ml distilled water), and the control group was injected with the same amount of distilled water. Inject once a day, five days a week. The effects of reducing blood pressure and preventing stroke in naturally occurring hypertension and stroke rats were observed.

[0018] (2) Measuring indicators:

[0019] Systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) were measured once a week before and after the experiment.

[0020] In the fourth week of administration, 24-hour urine was collected to measure the excretion of NO and the like.

[0021] After four weeks of administration, Laser-Doppler blood flow imaging was used to measure blood flow...

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Abstract

The invention relates to the use of 1-aminocyclopropanecarboxylic acid (ACPC) in preparing medicine for treating cerebrovascular and cardiovascular diseases, in particular the use in preparing medicament for treating hypertension, cerebrovascular thrombus and cerebral apoplexy.

Description

(1) Technical field [0001] The present invention relates to the new application of α-cycloalanine (ACPC) in the preparation of drugs for the treatment of cardiovascular and cerebrovascular diseases, especially in the preparation of drugs for the prevention and treatment of hypertension, cardiovascular and cerebrovascular thrombosis, cerebral apoplexy and protection of cerebral blood vessels, Applications in heart and kidney medicine. (2) Background technology [0002] α-Cycloalanine (1-aminocyclopropanecarboxylic acid, ACPC) is a natural non-protein special amino acid, which is currently mainly used to prepare poultry feed additives. It has been reported that α-Cyclopropanecarboxylic acid (ACPC) can be used to prepare drugs for the treatment of mental diseases , such as anxiety, depression, etc., there is no relevant report on the application of α-cycloalanine in the preparation of drugs for cardiovascular and cerebrovascular diseases. (3) Contents of the invention [000...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61P7/02A61P9/00A61P9/12
Inventor 朱旭祥高明
Owner 朱旭祥
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