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Dispersive tablet having allopurinol and benzbromarone

A technology of benzbromarone and dispersible tablets, applied in the directions of heterocyclic compound active ingredients, pill delivery, bone diseases, etc., can solve problems such as leukopenia, liver and kidney function damage, etc., and achieve high bioavailability, fast absorption, taking handy effect

Inactive Publication Date: 2005-05-18
健民集团叶开泰健康产业武汉有限公司
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  • Summary
  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, there are three commonly used drugs for the treatment of gout: colchicine, non-steroidal anti-inflammatory drugs and adrenal corticosteroids. Gastrointestinal reactions such as vomiting and diarrhea, suppression of bone marrow, or reduction of white blood cells, and damage to liver and kidney functions, etc.

Method used

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Examples

Experimental program
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Effect test

example 1

[0016] Take 100g of allopurinol and 20g of benzbromarone, and mix them uniformly according to the method of equal increase; take another 100g of microcrystalline cellulose, 20g of sodium carboxymethyl starch and 2g of micropowder silica gel, and add them to allopurinol and Benzbromarone mixture, mix well. Use PVP solution as binder to make soft material, granulate, dry and granulate. In addition, 2 g of micropowder silica gel and 2 g of sodium lauryl sulfate were mixed evenly with the prepared granules, and pressed into tablets to obtain dispersible tablets.

[0017] This medicine is used for various pathological elevated blood uric acid (hyperuricemia); clinical complications caused by elevated uric acid, especially symptomatic gout; various diseases that can cause elevated blood uric acid (secondary hyperuricemia), etc.

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Abstract

The dispersive allopurinol and benzbromarone tablet has allopurinol and benzbromarone in the ratio of 5, and can disintegrate completely in 100 ml water at 20 deg.c within 3 min and through No. 2 sieve. It has the functions of treating various kinds of hyperuricemia and its clinical complications, especially gout with symptom, as well as various diseases resulting in raised uric acid in blood.

Description

1. Technical field [0001] The present invention belongs to a kind of chemical medicine, specifically, it is a kind of treatment various pathological blood uric acid elevation (hyperuricemia); Clinical complication caused by uric acid elevation, especially symptomatic gout; Various The present invention provides a new preparation of chemicals that can cause diseases such as elevated blood uric acid (secondary hyperuricemia). 2. Technical background [0002] Gout is a disease caused by purine metabolism disorder and continuous increase of blood uric acid due to hereditary or acquired etiology. The clinical features include hyperuricemia, recurrent gouty acute arthritis, etc. If the treatment is not timely, the course of the disease is protracted and progresses slowly, which can easily cause various complications. Currently, there are three commonly used drugs for the treatment of gout: colchicine, non-steroidal anti-inflammatory drugs and adrenal cortico...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/522A61P19/06
Inventor 曹智华刘文鞠瑞芬黄志军
Owner 健民集团叶开泰健康产业武汉有限公司
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