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Yellow pigment of safflower preparation method and application

A technology of safflower yellow pigment and safflower, which is applied in the direction of chemical instruments and methods, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problems that there are no medicines or health care preparations, etc., shorten production time, improve Good purity and stability

Inactive Publication Date: 2005-03-30
ZHEJIANG YONGNING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, at present, only crude safflower yellow prepared by water extraction and alcohol precipitation method is used as food pigment, and there is no medicine or health product preparation based on high-purity fine safflower yellow

Method used

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  • Yellow pigment of safflower preparation method and application
  • Yellow pigment of safflower preparation method and application
  • Yellow pigment of safflower preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0159] Take safflower medicinal powder, add 10 times of water, heat to 100°C, keep warm for 30 minutes, filter and cool the filtrate. Add 10 times water to the filter residue, heat to 100°C, keep warm for 20 minutes, filter, cool, and combine the filtrate to stand for 4 hours. After the supernatant is centrifuged, use an ultrafiltration membrane to remove macromolecular impurities. Adsorbent resin D 4020 Column adsorption, deionized water elution, collected eluate, concentrated by membrane, concentrated solution was subjected to molecular sieve chromatography, and the loading amount was 6% of the volume of the chromatographic column. Elute with distilled water, collect the eluate and concentrate, and freeze-dry the concentrate to obtain safflower yellow; determined by high performance liquid chromatography, the content of safflower yellow is 88.6%. See attached figure 1 .

Embodiment 2

[0161] Take safflower medicinal powder, add 10 times of water, heat to 100°C, keep warm for 30 minutes, filter and cool the filtrate. Add 10 times water to the filter residue, heat to 100°C, keep warm for 20 minutes, filter, cool, and combine the filtrate to stand for 4 hours. After the supernatant is centrifuged, use an ultrafiltration membrane to remove macromolecular impurities. Adsorbent resin D 4020 Column adsorption, deionized water elution, collect the eluate, concentrate through the membrane, the concentrated solution is subjected to molecular sieve chromatography, and the loading amount is 10% of the volume of the chromatographic column. Elute with distilled water, collect the eluate to concentrate, apply Sephadex LH-20 column chromatography on the concentrated solution, collect the eluate, and freeze-dry to obtain safflower yellow; determined by high performance liquid chromatography, the content of safflower yellow is 99.6% . See attached figure 2 .

Embodiment 3

[0163] Take safflower medicinal powder, add 10 times of water, heat to 90°C, keep warm for 40 minutes, filter and cool the filtrate. Add 8 times of water to the filter residue, heat to 90°C, keep warm for 20 minutes, filter, and cool. Then add 8 times of water to the filter residue, heat to 90°C, keep warm for 20 minutes, filter, cool, and combine the filtrate to stand for 2 hours. After the supernatant is centrifuged, use an ultrafiltration membrane to remove macromolecular impurities. Macroporous Adsorption Resin D 4020 Adsorption, elution with deionized water, collection of the eluate, concentration through the membrane, the concentrated solution was subjected to molecular sieve chromatography, and the loading amount was 12% of the volume of the chromatographic column. Elute with distilled water, collect the eluate, and freeze-dry to obtain safflower yellow; determined by high-performance liquid chromatography, the content of safflower yellow is 86.1%. See attached imag...

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Abstract

This invention provides safflower uranidin prepd. from the Chinese herb medicine-safflower which isu sed for promoting blood circulation and removing blood disturbance, and the prepn. method and usage therefor. Said safflower uranidin is tested by high efficiency liquid phase chromatography with its content of 70-99.6%. It can be used for treating and preventing various kinds of diseases, such as cardiovascular disease, cerebrovascular disease and other blood circulation disturbance disease.

Description

technical field [0001] The invention relates to a safflower yellow prepared from safflower, a traditional Chinese medicine for promoting blood circulation and removing stasis, a preparation method thereof, and a new application of the safflower yellow. Background technique [0002] The traditional Chinese medicine safflower is the dried flower of Carthamus tinctorius L., a plant of Compositae. It is a common traditional Chinese medicine for promoting blood circulation and removing stasis. Safflower yellow is the main active ingredient in safflower, which is a chalcone glucoside [see: "Isolation and Identification of Yellow and Red Pigments in Safflower" in "Chinese Herbal Medicine", Volume 21, Issue 4, 1990 by An Xiqiang et al. ; Takahashi Yet al Lett1982; 23 (49): 5163; Zhang Linping "National Safflower Medicinal Academic Conference Proceedings" P24-27 "Safflower Powder Injection Physicochemical Properties Research", August 1996; Wang Chengsong et al. Chinese Patent Medici...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P9/00C09B61/00
Inventor 张建宇陆仙芸林德君徐升亮贺文彬黄海燕彭黎明卢敏
Owner ZHEJIANG YONGNING PHARMA
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