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Process for enzymatic synthesis of ethyl lactate in solvent phase

A technology of ethyl lactate and solvent phase, which is applied in the field of enzyme-catalyzed synthesis of ethyl lactate, can solve the problems of long production cycle, high consumption of raw materials, poor product quality, etc., and achieves high product quality and yield, mild reaction conditions, and no environment. The effect of pollution

Inactive Publication Date: 2005-03-16
HEBEI UNIV OF TECH
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Problems solved by technology

The above-mentioned production process has the following problems due to its own technology: (1) lactic acid is decomposed into acetaldehyde and formic acid when it is heated together with dilute sulfuric acid, and generates lactide when it is heated together with a dehydrating agent; (2) ethyl lactate is completely mixed with water Miscible; (3) Lactic acid raw material itself contains about 20% water
Therefore, the yield of lactic acid is low, only 55-65%, the consumption of raw materials is high, the production cycle is long, and the product quality is poor. Ethyl lactate has an obvious smell of benzene, which does not meet food hygiene standards.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0009] Raw material composition: lactic acid (85%), absolute ethanol

[0010] Lactic acid: ethanol (molar ratio) = 1:9, 0.5 g of the mixed reactants in total, Humicola tomentosa lipase was used as the catalyst, the dosage was 50 mg, and 5 mL of tetrahydrofuran was added as a solvent.

[0011] The above raw materials were sequentially added into a 50 mL Erlenmeyer flask with a stopper, and the constant temperature water bath oscillator was controlled at a temperature of 70° C. and a rotation speed of 200 rpm, and reacted for 24 hours. The resulting product was analyzed by gas chromatography, and the yield of ethyl lactate was 73.9%.

example 2

[0013] Raw material composition: lactic acid (85%), ethanol (anhydrous)

[0014] Lactic acid:ethanol (molar ratio)=1:6, the mixed reactant was 0.7g in total, the catalyst was immobilized Candida antarctica lipase B, the dosage was 80mg, and 5mL of chloroform was added as solvent.

[0015] The above raw materials were sequentially added into a 50 ml Erlenmeyer flask with a stopper, and the temperature was controlled by a constant temperature water bath oscillator at 60° C., and the number of revolutions was 250 rpm, and the reaction was carried out for 48 hours. The resulting product was analyzed by gas chromatography, and the yield of ethyl lactate was 76.4%.

example 3

[0017] Raw material composition: lactic acid (85%), ethanol (anhydrous)

[0018] Lactic acid: ethanol (molar ratio) = 1:8, the mixed reaction product is 0.7 g in total, the catalyst uses immobilized mucormyces lipase, the dosage is 80 mg, and 5 mL of tert-butanol is added as a solvent.

[0019] The above raw materials were sequentially added into a 50 mL Erlenmeyer flask with a stopper, and the constant temperature water bath oscillator was controlled at a temperature of 60° C., with a rotation speed of 200 rpm, and reacted for 24 hours. The resulting product was analyzed by gas chromatography, and the yield of ethyl lactate was 73.5%.

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Abstract

The invention discloses a ethyl lactate synthesis enzyme catalysis method in solvent phase and belongs to ethyl lactate preparation technology using lactic acid and ethanol, characterizing in the following steps: using chloroform, tert-butanol or tetrahydrofuran as sovent, or adding in the said solvent of lactic acid and ethanol in ratio of (1:5)-(1:10) and lipase according to 10-30 g enzyme catalysis per mol lactic acid, mixing sufficiently, constant temperature water bath in 60-70 DEG C while lactic acid concentration is 0.3-0.6mol / L, concussion table revolution being controlled 200-250revolution / min, reacting 24-48 hours, obtaining crude products containing ethyl lactate. Advantage of the invention compared with existing ethyl lactate preparation method lies in: temperate reaction condition, low energy consumption, easy operation of separating catalyst and products, apparatus not easy corroding, no pollution, high product quality and yield.

Description

technical field [0001] The invention relates to a method for enzymatically synthesizing ethyl lactate in a solvent phase, which belongs to the technology of preparing ethyl lactate with lactic acid and ethanol. technical background [0002] At present, most manufacturers of ethyl lactate adopt the traditional process of concentrated sulfuric acid catalysis and benzene dehydration and esterification. The process is briefly described as follows: lactic acid (content 80%) and ethanol (92-93%) are mixed according to a certain proportion, concentrated sulfuric acid is added as a catalyst, and a large amount of benzene is added as a dehydrating agent. Then in the esterification tank (tower) heating reflux esterification, benzene, ethanol and water form a ternary azeotrope to remove the water contained in the raw material and the water produced in the esterification process, so as to increase the formation of lactic acid Ester rate. After the ester...

Claims

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Application Information

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IPC IPC(8): C12P7/62
Inventor 高静赵天涛赵学明
Owner HEBEI UNIV OF TECH
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