Orally disintegrating tablet of 'Shengmai' and its preparation

A technology of orally disintegrating tablets and Shengmai, which is applied in the direction of medical formulas, medical preparations containing active ingredients, pill delivery, etc. quick effect

Inactive Publication Date: 2005-03-16
张晴龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The Shengmai capsule with the standard number WS3-B-1312 records the extraction method. During the extraction process, ginseng polysaccharides, Ophiopogon polysaccharides, and Schisandra polysaccharides were not extracted, and part of the active ingredients were discarded. It is a pity (China Pharmaceutical University Acta Sinica, 2002, 33(1): 38-41); no patents related to Shengmai orally disintegrating tablets were found

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0122] (1) raw material prescription of the present invention is:

[0123] Ginseng is 330 grams, Ophiopogon japonicus is 660 grams, Schisandra is 330 grams;

[0124] (2) Take ginseng and Ophiopogon japonicus slices, crush them, put them into a multifunctional extracting tank of traditional Chinese medicine, extract them with 6 times of ethanol at a concentration of 50% for 1 hour, extract twice, filter, and combine the extracts to reclaim the ethanol to the utmost, after extraction The residue is dried and used for later use; the extract is placed on a D101 macroporous adsorption resin column, and firstly eluted with distilled water, which is 10 times the volume of the column for elution, and the eluent is discarded, and then eluted with 50%. The ethanol is 6 times of the column volume, and the ethanol is recovered from the eluent to the utmost extent to obtain 16.0 grams of effective fractions of ginseng and Radix Ophiopogon japonicus;

[0125] (3) Take schisandra, pulverize...

Embodiment 2

[0131] (1) raw material prescription of the present invention is:

[0132] Ginseng is 330 grams, Ophiopogon japonicus is 660 grams, Schisandra is 330 grams;

[0133] (2) Take ginseng and Ophiopogon japonicus slices, pulverize them, put them into a Chinese medicine multifunctional extraction tank, extract them with 8 times, 80% ethanol for 3 hours, extract 4 times, filter, and combine the extracts to reclaim the ethanol to the utmost, after extraction The residue is dried and used for later use; the extract is put on the AB-8 type macroporous adsorption resin column, and first eluted with distilled water, which is 15 times the volume of the column for elution, and the eluent is discarded, and then 80% is used for elution. The ethanol used for removal is 10 times the volume of the column, and the ethanol is recovered from the eluent to the utmost extent to obtain 33.0 g of effective fractions of ginseng and Radix Ophiopogon japonicus;

[0134] (3) Take schisandra, pulverize, pu...

Embodiment 3

[0139] (1) raw material prescription of the present invention is:

[0140] Ginseng is 330 grams, Ophiopogon japonicus is 660 grams, Schisandra is 330 grams;

[0141] (2) Take ginseng and Ophiopogon japonicus slices, pulverize them, put them into a multifunctional extracting tank of traditional Chinese medicine, extract them with 7 times and 55% ethanol for 2 hours, extract 3 times, filter, and combine the extracts to reclaim the ethanol to the utmost, after extraction The residue is dried and used for later use; the extract is put on the NKA macroporous adsorption resin column, and firstly eluted with distilled water, which is 11 times the volume of the column for elution, and the eluent is discarded, and then eluted with 55, and ethanol is used for elution. 7 times the volume of the column, the ethanol was recovered from the eluent to the utmost extent, and 29.4 grams of effective parts of ginseng and Radix Ophiopogon were obtained;

[0142] (3) Take schisandra, pulverize, p...

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PUM

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Abstract

The invention discloses an orally disintegrating tablet of 'Shengmai' and its preparation characterized in that the tablet comprises the significant portions extracted from traditional Chinese medicinal panax ginseng, ophiopogon root, schisandra fruit and other medical use findings, the invention is also characterized that composite disintegrating tablet containing tetrahydroxy butane is employed, wherein the composite disintegrating tablet is obtained by combining tetrahydroxy butane with low substituted Hydroxypropylmethyl cellulose or sodium carboxymethylstarch or crossbond sodium carboxymethylstarch or insoluble cross bond polyvinylpyrrolidone by a finite proportion, the tetrahydroxy butane has the action of taste rectifying agent, thus reducing the consumption of medicinal findings in the preparation. Pharmacological experiment has shown that the disintegrating tablet has the advantages of quick disintegration, fast effect, and better pharmacological actions.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a Shengmai orally disintegrating tablet and a preparation method thereof. Background technique [0002] Orally disintegrating tablets are a new pharmaceutical preparation, which can be absorbed through the sublingual mucosa and directly enter the blood, effectively avoiding the first-pass effect, so the dosage is small, safe and has a rapid effect. Although it is an oral preparation, it can achieve the effect of an injection preparation. Therefore, it is gradually becoming a hot spot in the field of pharmaceutical companies and research and development. The dosage form is mainly to select a suitable fast disintegrating agent, and the tablet made of it has a certain hardness and a certain degree of porosity. When taking it, it does not need water to assist swallowing, and it can quickly disintegrate into fine particles in the mouth, and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61P9/00A61P9/10
Inventor 张晴龙
Owner 张晴龙
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