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High performance antibiotic medicine composition

A technology of antibacterial drugs and compositions, applied in the field of high-efficiency antibacterial drug compositions, can solve the problems of no sulbactam and azlocillin sodium, etc., and achieve the effects of easy popularization and application, inhibiting activity, and solving drug resistance.

Inactive Publication Date: 2005-03-02
陶灵刚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This product has only weak antibacterial effect, so it cannot be used alone as an antibacterial drug. It is mainly compatible with β-lactam antibiotics and used for various severe infections and drug-resistant strains. At present, there is no combination of sulbactam and albino The compound of loxcillin sodium is applied

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Take 1.0g of azlocillin sodium and 10.0000g of sulbactam, mix them evenly, and sub-pack them in a class 100 clean area that meets the requirements of GMP at a relative humidity below 45%.

Embodiment 2

[0031] Take 2.0g of azlocillin sodium and 0.2000g of sulbactam, mix them evenly, and sub-pack them in a class 100 clean area that meets the requirements of GMP at a relative humidity below 45%.

Embodiment 3

[0033] Take 1.0 g of azlocillin sodium and 1.0000 g of sulbactam, mix them evenly, and sub-pack them in a class 100 clean area that meets the requirements of GMP at a relative humidity below 45%.

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PUM

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Abstract

The present invention relates to high efficiency antibiotic medicine composition containing azlocillin sodium and sulbactam in the weight ratio of 0.1-10, optimally of 1-4. The medicine composition has obvious cooperative effect of azlocillin sodium and sulbactam and antibiotic capacity much higher than azlocillin sodium. The present invention has wide antibiotic spectrum, powerful bactericidal effect, high chemical stability and low toxicity, and the medicine composition is prepared into injection normally.

Description

technical field [0001] The present invention relates to a high-efficiency antibacterial drug composition, more specifically relates to a high-efficiency antibacterial drug composition containing azlocillin sodium and sulbactam. Background technique [0002] As we all know, due to the long-term and extensive use or even abuse of antibiotics in clinical practice, the resistance of bacteria to antibiotics has become stronger and stronger, for example, the important pathogenic bacteria of bacterial meningitis, otitis media, sepsis and pneumonia caused by Streptococcus pneumoniae , is the main pathogenic bacteria of children's out-of-hospital infection, and the first pathogenic bacteria of adults, especially the elderly, in the community. Due to the resistance of Streptococcus pneumoniae to penicillin and other β-lactam antibiotics, in the 1990s Since then, penicillin-resistant Streptococcus pneumoniae has spread widely around the world, and the therapeu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/43A61P31/04
Inventor 陈胜龙
Owner 陶灵刚
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