Amino protective reagent azido tert.-butyl formate synthesizing method
A technology of amino protection and synthesis method, which is applied in the direction of organic chemistry, can solve the problems of cumbersome synthesis route and not widely used, and achieve the effect of simple synthesis route, low toxicity and less side reactions
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[0039] Add 52.5 grams of tert-butanol (0.71 moles) in a 500 milliliter three-necked flask, 55 milliliters of pyridine (0.71 moles) and 110 milliliters of chloroform, ice water cooling (0 ℃), add ethyl chloroformate under stirring in 2 hours ( 0.71 mol). The reaction produced a large amount of precipitate. The reaction was continued for 24 hours. 83 g of pale yellow oily liquid (CH 3 ) 3 COCOO Et.
[0040] The product (CH 3 ) 3 COCOOEt (64g, 0.44mol) was placed in a three-necked flask, and 25ml of 85wt% hydrated NH 2 NH 2 (0.44 mol) solution, refluxed at 110°C for 12 hours. 46 g of a waxy solid (CH 3 ) 3 COCONHNH 2 .
[0041] Weigh 9.9 g (CH 3 ) 3 COCONHNH 2 (0.075 mol) was dissolved in 9 ml of acetic acid (0.15 mol) and 12 ml of water, and 6.2 g of NaNO was added dropwise at 0°C in an ice bath 2 (0.09 mol) in 10 ml of aqueous solution. The reaction was continued for 2 hours. 10 g of light yellow-green oily liquid (CH 3 ) 3COCON 3 .
[0042] IR data charac...
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