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Use of cornel and its extract in preparation alpha-glucosidase inhibitor medicine

A technology of glucosidase and cornus, which is applied in the directions of drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of limited effect of reducing postprandial blood sugar, no application report of cornus, etc., and achieves extraction and preparation. The method is simple and easy to implement, inhibits the activity of α-glucosidase, and has the effect of sufficient drug sources

Inactive Publication Date: 2005-01-19
CHENGDU DIAO PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] For many years, the main goal of diabetes treatment is to control fasting blood sugar. For a long time, only sulfonylureas and biguanides have been used as therapeutic drugs. Sulfonylureas lower blood sugar by stimulating the secretion of insulin from the pancreas; As for hypoglycemia, both have a good effect on reducing fasting blood sugar in patients with type II diabetes, but have very limited effects on reducing postprandial blood sugar.
However, there is no report on the application of Cornus officinalis in the preparation of drugs with α-glucosidase inhibitory activity, and there is no report of the total glycosides extract of Cornus officinalis with α-glucosidase inhibitory activity in the preparation of reducing postprandial blood sugar and treating type I and II diabetes. And application reports in drugs for diabetic complications

Method used

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  • Use of cornel and its extract in preparation alpha-glucosidase inhibitor medicine
  • Use of cornel and its extract in preparation alpha-glucosidase inhibitor medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 Preparation of Cornus officinalis extract SZY-1 (soaked in ethanol):

[0020] After crushing 200 grams of dried Cornus officinalis, reflux three times with 5 times the amount of 70% ethanol, each time for 0.5 hours; filter the ethanol extracts, combine them, and concentrate to dryness under reduced pressure to obtain 45 g of extract SZY-1.

[0021] With morroniside as contrasting standard substance, with spectrophotometry (Zheng Huzhan etc., modern research and application of Chinese medicine, the 48th page), the total glucosides of cornus officinalis in the dry powder product is determined, the total glucosides of cornus officinalis (weight ratio ) is 15%. Use indigo carmine solution as indicator agent and standard KMnO 4 The solution was titrated, and the measured polyphenol content was 9%.

Embodiment 2

[0022] Example 2 Preparation of Cornus officinalis Extract SZY-2:

[0023] After 200 grams of dry Cornus officinalis is crushed, reflux three times with 5 times the amount of 60% ethanol successively, each time for 0.5 hours; filter the ethanol extracts and combine them, distill the ethanol off under reduced pressure to obtain a concentrated aqueous solution, dilute it with deionized water to 1600ml, centrifuged for later use. Get 200 grams of D-140 type non-polar macroporous resin packing column, above-mentioned aqueous solution is passed through this macroporous resin column with the flow velocity of 20 milliliters / minute, then wash column with the flow velocity of 20 milliliters / minute with 500 milliliters of deionized water, Then eluted with 1000 ml of 75% ethanol, combined the eluents, concentrated under reduced pressure, and dried in vacuum to obtain 8.593 g of Cornus officinalis extract SZY-2, which was brown powder. Appropriate auxiliary materials can be added to make...

Embodiment 3

[0025] Example 3 Preparation of Cornus officinalis Extract SZY-3:

[0026] After crushing 200 grams of dried Cornus officinalis, add 10 times the amount of water and decoct for 30 minutes, and decoct three times in total. The three decoctions were combined and centrifuged for later use. Get 200 grams of D-140 type non-polar macroporous resin packing column, the above-mentioned decoction is passed through this macroporous resin column with a flow rate of 20 ml / min, and then washed with 500 ml of deionized water at a flow rate of 20 ml / min The column was eluted with 1000 ml of 75% ethanol, and the eluents were combined, concentrated under reduced pressure, and vacuum-dried to obtain 8.789 g of Cornus officinalis extract SZY-3. Appropriate auxiliary materials can be added to make tablets, capsules and granules.

[0027] Using morroniside as a reference standard, the content of total glucosides of Cornus officinalis in the above dry powder product was determined by spectrophotomet...

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Abstract

The invention provides a dogberry medicament having alpha-glucosaminidase inhibiting activity, and the water or organic solvent extract of dogberry, wherein the dogberry extract comprises total glycosides and poly phenols constitution.

Description

technical field [0001] The present invention relates to the new medicinal application of traditional Chinese medicine and its extract, specifically, the present invention relates to the application of Chinese medicine Cornus officinalis Sieb. et Zucc and its extract in the preparation of α-glucosidase inhibitor drugs, It can reduce postprandial blood sugar, treat type I and type II diabetes and diabetic complications. Background technique [0002] For many years, the main goal of diabetes treatment is to control fasting blood sugar. For a long time, only sulfonylureas and biguanides have been used as therapeutic drugs. Sulfonylureas lower blood sugar by stimulating the secretion of insulin from the pancreas; As for hypoglycemia, both of them have a good effect on reducing fasting blood sugar in patients with type II diabetes, but they have very limited effects on reducing postprandial blood sugar. Postprandial blood sugar in diabetes is the highest s...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P3/10
Inventor 高小平罗弟祥徐大勇刘忠荣李伯刚邹文俊黄瑜
Owner CHENGDU DIAO PHARMA GROUP
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