Adherence peptide specific to tissue of liver cancer, screen method combined between in vivo and in vitro, and usage

Abstract

The invention relates to an adherent peptide capable of specifically combining hepatocarcinoma tissue/cell, screening method of said adherent peptide and application of said adherent peptide, belonging to the field of molecular pharmacology technology. The internal and external combined screening method provided by said invention has the advantages of internal screening method and external screening method, and can overcome their defects, and two kinds of hepatocarcinoma tissue/cell adherent peptides can be screened out, and their polypeptide sequences ore determined. Said hepatocarcinoma tissue/cell specific adherent peptides have good guide effect and strong tissue distribution specificity, and have broad application prospects in preparation of guide medicine for curing hepatocarcinoma.

Description

technical field [0001] The present invention relates to a targeting peptide in tumor-guiding therapy, a screening method for the targeting peptide, and an application of the targeting peptide, in particular to an adhesion peptide that can specifically bind liver cancer tissue / cells, and the adhesion peptide The screening method and the application of the adhesion peptide belong to the technical field of molecular pharmacology. technical background [0002] Liver cancer, as one of the most common malignant tumors, poses a great threat to human health. It is estimated that 1.25 million patients die of liver cancer every year in the world. The methods currently used for the treatment of liver cancer mainly include surgical therapy, radiotherapy and chemotherapy, etc., but these methods have different degrees of side effects on healthy tissues and organs of the human body. [0003] Guided therapy technology has opened up broad prospects for the treatme...

AI Technical Summary

Problems solved by technology

However, the obvious defect of the in vivo screening method is that it is more cumbersome and difficult than the in vitro screening method in terms of screening and identification, so most reports still use the in vitro screening method of cells

However, although in vitro screening and identification are simpler than in vivo screening, its disadvantages are also obvious, because the environment of cells cultured in vitro is quite different from that in vivo, so it is impossible to accurately judge the specificity of the targeting peptides screened.

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