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Crystallizing and purifying Method for preparing puerarin in high purification

A purification method and puerarin technology, applied in the field of purification and purification of natural substances, can solve the problems of low yield, long time, and difficulty in reaching 97% purity, and achieve the effects of simple process and high yield

Inactive Publication Date: 2005-01-12
HEFEI UNIV OF TECH
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AI Technical Summary

Problems solved by technology

[0005] At present, the preparation of high-purity puerarin mostly adopts repeated crystallization of organic solvents or preparation of chromatographic separation methods, which take a long time and have low yields, and the purity is difficult to reach more than 97%.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0022] Now about 90% puerarin extract is used as raw material, and the non-limiting examples are described as follows.

[0023] 1. Take the raw materials and ethanol, mix them according to the solid-liquid ratio (mg / ml, the same below) of 1:10-15, heat and dissolve them, place them in a magnetic field of 0.1 Tesla to induce static crystallization, filter the crystals, repeat Electromagnetically induced crystallization for 2 to 5 times, and finally dried at 100°C, the purity of white crystal puerarin was 99.2%.

[0024] 2. Get the raw materials and water, mix them at a solid-to-liquid ratio of 1:10 to 15, heat to dissolve, induce crystallization at 70 to 80° C. and 10 tesla electromagnetically, and the remaining operations are the same as in Example 1. The purity of white crystal puerarin is 99.2%.

[0025] 3. Take the raw materials and propanol, mix them at a solid-to-liquid ratio of 1:15 to 20, heat to dissolve, induce crystallization at 50 to 60° C. and 2 tesla electromagnet...

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Abstract

This invention relates crystallization purification method for producing super pure microestrol by using miroestrol extractum as raw material, being dissolved insolvent. said supersaturated solution is placed constant or varying magnetic field with magnetic flux of 0.1-10 tesla, after each crystallization, the purity is higher than 95%; and after 2-5 crystallization, the purity of the product is over 99.7%. This invention crystallization method is sipmle, no need of refrigeration drying or spray-drying method which are energy-consumption process. This invention method has advantages of: commercialization prodn., and super high purity product of standard product of miroestrol.

Description

1. Technical field [0001] The invention relates to a method for refining and purifying natural substances, in particular to a method for crystallization and purification, to be precise, a method for crystallization and purification of high-purity puerarin. 2. Background technology [0002] Pueraria lobata has a long history as a blind medicine in the proven prescriptions of Chinese herbal medicine for disease prevention and treatment. The puerarin content of its crude drug puerarin in the currently listed puerarin injection usually only reaches about 90% (HPLC method). Its preparation process mainly refers to the chemical research on the components of kudzu root, "Journal of Pharmaceutical Sciences" 1959, 79:755; Fang Qicheng, etc. : the research of kudzu root flavonoids, "Chinese Medical Journal" 1974,54:271) method, namely with n-butanol-water liquid-liquid extraction with ethanol extract, aluminum oxide decolorization, glacial acetic acid crystallization. Due to the lar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H1/06C07H17/07
Inventor 潘见王华峰
Owner HEFEI UNIV OF TECH
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