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Process of preparing ganoderma tricterpinyl acid and ganoderma polyose from ganoderma

A technology of Ganoderma lucidum triterpenoid acid and Ganoderma lucidum polysaccharide, applied in chemical instruments and methods, preparation of steroids, pharmaceutical formulations, etc., can solve the problems of low content of Ganoderma lucidum triterpenoid acid and the like

Inactive Publication Date: 2005-01-05
北京云威科技有限公司
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AI Technical Summary

Problems solved by technology

Chinese patent CN1181271 introduces the use of low-pressure water boiling process. Due to the relatively low temperature (55-85°C), the pharmacological activity of polysaccharides is 3-5 times higher than that of conventional water boiling (100-110°C). Ganoderma lucidum is low in triterpene acids

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: Weigh 200g of Ganoderma lucidum flakes, add supercritical CO 2 In the extraction tank, first wet it with 500ml ethyl acetate, and extract statically at 30Mpa, 40°C for 15min. 99.5-99.995% pure CO 2 The flow rate is 120ml / min, continuous dynamic extraction for 0.5 hours to remove fat-soluble impurities. Thereafter, ethyl acetate was used as a polar agent (24ml / min), and the ganoderma triterpene acid was extracted for another 3 hours under the supercritical conditions of 30Mpa and 40°C. As a result, 5.1 g of Ganoderma lucidum triterpene acid extract was obtained in the form of brownish-yellow extract, and the content of Ganoderma lucidum triterpene acid was 32.5%.

[0023] In a high pressure tank (i.e. supercritical CO 2 The extracted raffinate in the extraction tank) is then extracted with 8 times the amount of water at 80°C for 1.5 hours, extracted 3 times successively, concentrated in a three-effect concentration tank at low temperature (below 60°C) un...

Embodiment 2

[0025] Example 2: Weigh 200g of Ganoderma lucidum flakes, first wet it with 500ml ethanol, extract it statically at 35Mpa, 80°C for 15min, and then extract it at 25Mpa, 80°C, CO 2 The flow rate is 120ml / min, continuous dynamic extraction for 0.5 hours to remove fat-soluble impurities. Thereafter, ethanol was used as polar agent (24ml / min), and Ganoderma triterpene acid was extracted for 3 hours under supercritical conditions of 25Mpa and 80°C. As a result, 5.2 g of Ganoderma lucidum triterpene acid extract was obtained, wherein the content of Ganoderma lucidum triterpene acid was 42.5%. The extracted raffinate was then extracted with 8 times the amount of water at 70°C for 1 hour, extracted 3 times successively, and after low-temperature concentration and drying, 10.0 g of Ganoderma lucidum polysaccharide in the form of brownish-yellow extract was obtained, which contained 36% of Ganoderma lucidum polysaccharide .

Embodiment 3

[0026] Example 3: Ganoderma lucidum raw material 200g, the dynamic extraction conditions are 50MPa, 50°C, the polar agent dosage is 18mL / min, the rest is the same as in Example 2, and the result is 6.0g of Ganoderma lucidum triterpene acid extract with a content of 36.0%. Obtaining Ganoderma lucidum polysaccharide Extract 9.6g, content is 34%.

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Abstract

The invention is a method of preparing glossy ganoderma triterpenic acid and amylase by glossy ganoderma, crushing the dry glossy ganoderma seeds (water content 5-8%) into particles; or cutting into slices, then putting raw material in a high-pressure extraction kettle, then injecting CO2 and polar agent in the extraction kettle by a supercritical CO2 high-pressure pump and a polar agent pump, respetively, where the extracting pressure of the high-pressure pump is 25-50 MPa, the injection quantity of the polar agent in bulk percent is 10-20%, the temperature is 35-80 deg.C, and the extracting time 2-4 hours, obtaining the extract of glossy ganoderma triterpenic acid; adding water by 8-16 times in the residues, heating to 80-100 deg.C, extracting for 1-2 hours, obtaining the extract of glossy ganoderma amylase. In the products prepared by this invention, the content of glossy ganoderma triterpenic acid is up to 60.2% (by HPLC detection); that of glossy ganoderma amylase 36% (by UV spectral detection).

Description

technical field [0001] The invention relates to a method for preparing ganoderma triterpene acids and ganoderma polysaccharides from ganoderma, in particular to a method for preparing ganoderma triterpene acids and ganoderma polysaccharides from ganoderma using supercritical combination technology. Background technique [0002] Ganoderma lucidum is a traditional Chinese medicine that was once called "the fairy grass". Modern pharmaceutical research shows that it has the functions of anti-aging, anti-inflammation and liver protection, improving human immunity, inhibiting tumors and anti-AIDS (HIV-1). It contains a variety of biologically active substances, the two most important of which are ganoderma triterpene acids and ganoderma polysaccharides. [0003] At present, most of the traditional methods for preparing ganoderma triterpene acids and ganoderma polysaccharides use water boiling or alcohol extraction. Chinese patent CN1181271 introduces the use of low-pressure wate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D11/02C07J75/00C08B37/00
CPCY02P20/54
Inventor 廖幼鸣姚渭溪赵颖涛萧效良邓文龙王红
Owner 北京云威科技有限公司
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