Method of producing reduced coenzyme Q10

Abstract

The present invention relates to a method of conveniently and efficiently producing high-quality reduced coenzyme Q10 which is useful as an ingredient in foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, animal drugs, drinks, feeds, cosmetics, medicines, remedies, preventive drugs, etc. This method is suitable for industrial production thereof. A method of producing a reduced coenzyme Q10 which comprises reducing an oxidized coenzyme Q10 in an aqueous medium with the use of dithionous acid or a salt thereof, said reduction being carried out in the coexistence of a salt and / or under deoxygenated atmosphere, and at pH of 7 or below. Thus, the formation of the oxidized coenzyme Q10 as a by-product due to oxidation can be minimized, thereby giving reduced coenzyme Q10 having excellent qualities in a high yield.

Description

technical field [0001] The invention relates to a method for preparing reduced coenzyme Q 10 Methods. oxidized coenzyme Q 10 Compared to reduced coenzyme Q 10 Shows a higher oral absorption rate, and the compound can be used as beneficial food, functional nutritional food, special health food, nutritional supplement, nutrient, beverage, feed, animal drug, cosmetic, drug, therapeutic drug, preventive drug, etc. components. Background technique [0002] Known reduced coenzyme Q 10 The preparation method is as follows, coenzyme Q is prepared by conventional methods, such as synthesis, fermentation, or extraction from natural products 10 , and then concentrated to produce reduced coenzyme Q containing reduced coenzyme Q by chromatographic separation 10 Part of the eluate, that is, to obtain reduced coenzyme Q 10 (JP-A-10-109933). At this time, as described in the above citation, the reduced coenzyme Q can be reduced first with a reducing agent such as sodium borohydride ...

AI Technical Summary

Problems solved by technology

[0004] However, the inventors of the present application have initially studied the above-mentioned reduction method and found that the method is not easy to obtain high-quality reduced coenzyme Q with a higher yield. 10

[0005] The above-mentioned problems not only lead to economic disadvantages, but also cause problems such as contamination of oxidized coenzyme Q, which is difficult to remove, into the product. 10 and other quality issues

In addition, the heavy use of reducing agents will lead to an increased burden of reducing agent removal and decontamination of reducing agents, and produce some derived components

[0006] Thus, the disadvantages of the above-mentioned reduction reaction make further purification process more necessary