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Troxerutin injection and its preparation method

A technology of troxerutin and large infusion, which is applied in the direction of drug delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve the problems of unfavorable health of patients

Inactive Publication Date: 2004-08-18
四川中方制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Since troxerutin large infusion is clinically used in patients with cerebrovascular diseases, and the intake of sugar and salt must be restricted for such diseases, if glucose or sodium chloride is used as the osmotic pressure regulator, each 250ml preparation contains 12.5g Glucose or 2.25g sodium chloride, obviously not good for the patient's health

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0020] The preparation method of troxerutin large infusion adopts non-sodium chloride and non-glucose osmotic pressure regulator.

[0021] In the preparation method of troxerutin infusion, the osmotic pressure regulator used is sorbitol, fructose, mannitol or lactose.

[0022] In the preparation method of the troxerutin large infusion, the dosage of sorbitol in the large infusion is 5-10% (g / ml).

[0023] In the preparation method of the troxerutin large infusion, the dosage of fructose in the large infusion is 5-10% (g / ml).

[0024] In the preparation method of the troxerutin large infusion, the dosage of mannitol in the large infusion is 5-10% (g / ml).

[0025] In the preparation method of the troxerutin large infusion, the dosage of lactose in the large infusion is 13-20% (g / ml).

[0026] For the preparation method of the above-mentioned troxerutin large infusion, the production process of the large infusion can be any production process of the dosage form mentioned in pha...

Embodiment 1

[0031] Prescription: Sorbitol 50g Troxerutin 0.5g

[0032] Add water for injection to 1000ml

[0033] Preparation method: Put sorbitol into boiled water for injection according to the prescription amount to make a concentrated solution with a certain concentration, add 0.5% (g / ml) activated carbon in the concentrated solution, mix well, heat and boil for about 5 minutes, and filter while hot Decarbonize, and the filtrate is set aside.

[0034] Dissolve troxerutin in water for injection according to the prescription amount to make a concentrated solution of a certain concentration, add 0.5% (g / ml) activated carbon to the concentrated solution, mix well, heat and boil for about 5 minutes, filter while hot to decarbonize , and the filtrate is set aside.

[0035] Combine the sorbitol solution and the troxerutin solution, add water for injection to the specified amount, measure the pH and content to pass, filter repeatedly until clear, fill and seal, and sterilize by autoclaving ...

Embodiment 2

[0037] Prescription: Sorbitol 100g Troxerutin 10g

[0038] Add water for injection to 1000ml

[0039] Preparation method: Put sorbitol into boiling water for injection according to the prescription amount to make a concentrated solution with a certain concentration, add 2.0% (g / ml) activated carbon in the concentrated solution, mix well, heat and boil for about 30 minutes, and filter while hot Decarbonize, and the filtrate is set aside.

[0040] Dissolve troxerutin in water for injection according to the prescription amount to make a concentrated solution of a certain concentration, add 2.0% (g / ml) activated carbon to the concentrated solution, mix well, heat and boil for about 30 minutes, filter while hot to decarbonize , and the filtrate is set aside.

[0041] Combine the sorbitol solution and the troxerutin solution, add water for injection to the specified amount, measure the pH and content to pass, filter repeatedly until clear, fill and seal, and sterilize by autoclavi...

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Abstract

The present invention is one kind of transfused Troxerutin fluid and its preparation process. The transfused Troxerutin fluid includes Troxerutin and non-sodium chloride and non-glucose osmotic pressure regulator of sorbic alcohol, fructose, mannitol or lactose. The transfused Troxerutin fluid preparation accords with the clinical requirement for cerebral vascular disease in limiting sugar and salt intaking amount, and has the osmotic pressure regulating effect the same as that of transfused fluid containing glucose in 5 % or sodium chloride in 0.9 %.

Description

Technical field: [0001] The invention relates to a preparation method of a medicine, in particular to a troxerutin intravenous drip infusion solution and a preparation method thereof. Background technique: [0002] Troxerutin is a mixture of hydroxyethyl rutin mainly composed of 7,3',4'-trihydroxyethyl rutin obtained by hydroxyethylation of rutin, also known as Weinaolutong, which is easily soluble in water , Slightly soluble in methanol, very slightly soluble in ethanol, insoluble in chloroform. It is mainly used to treat occlusive cerebrovascular disease, arteriosclerosis, thrombophlebitis and other diseases, as well as various fundus diseases, such as retinal diseases caused by diabetes, retinal and vitreous hemorrhage, subconjunctival hemorrhage, retinal vascular embolism, etc. There are domestic pharmaceutical factories producing troxerutin and its tablets, capsules, oral liquids, injections (small injections), and troxerutin sodium chloride injection, which were origi...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/352A61P9/10A61P9/14
Inventor 李树明刘传捷胡坦莲
Owner 四川中方制药有限公司
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