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Antiperspirant composition friendly to skin and its preparation method

A technology of antiperspirant, composition, applied in 1%, antiperspirant composition, talc can produce chalking and health problems field, can solve problems such as bad skin feeling, chalking and so on

Inactive Publication Date: 2004-05-12
RIIHAISU INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, silica and talc can cause chalking and health problems, and the finished product has an unpleasant skin feel due to increased drag resistance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0064] 1700 g of basic aluminum chloride (Reach 301, product of Reheis) solution (11.9% Al, 9.5% Cl) was mixed with 125 g of glycerol. The mixture was placed in a Erlenmeyer flask equipped with a reflux device, refluxed for 4 hours, and cooled to room temperature. At room temperature, 1390 g of zirconium hydroxychloride (ZHC) glycine salt solution (13.5% Zr, 5.9% Cl, 11.2% glycine; ZHC solution and glycine were refluxed for 2 hours) was slowly added to the above-mentioned RE301 / glycerol solution, and finally The resulting solution was spray-dried to obtain a white powder, which was micronized to obtain the desired particle size distribution of the product.

Embodiment 3-7

[0066] The procedure of Example 2 was repeated except that the number of compounds used was scaled up to the level of the pilot plant. The results of Examples 3 through 7 in Table I illustrate the effect of the spray drying process. The input temperature is between 450-600°F and the output temperature is 235±5°F. Different sprayers, including CSE, porous metal, dual flow nozzle, MMDH, etc., were used to comprehensively characterize the physical and chemical properties of the powders.

[0067]The results presented in Table I comprehensively analyze the chemical properties, particle size, BET surface area, total mercury injected volume, total pore area and mean pore diameter for all samples. Particle size was analyzed with a Microtrack Model No. SRA150, and porosity data were measured with a Micromeritics Autopore Mercury Porosimeter Model No. 9520. The BET surface area was analyzed using a single-point BET instrument manufactured by Quanta Chrome Corporation.

[0068] ...

Embodiment 19

[0093] Examples 19, 20, 21 illustrate that when glycerol is mixed with ZHC glycinate solution at room temperature or at reflux temperature, the amount of complexed glycerin does not increase significantly. When glycerol was added to aluminum hydroxychloride at room temperature and mixed with the refluxing ZHC glycinate solution, the amount of glycerol complexed was somewhat less.

[0094] implement

[0095] A GL-Glycerol

[0096] b G-glycine

[0097] * Determined by titration analysis method

[0098] The examples in Table VI illustrate that the amount of glycerol complexed does not change significantly when mixed with aluminum hydroxychloride either at room temperature or at reflux for 2-4 hours.

[0099] The data in Table V and Table VI also show that the amount of glycerol complexed is a function of the glycerol concentration and at which reaction step the glycerol was added.

[0100] Reality

[0101] 1 Mix RE-301 with glycerol at room temperature...

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Abstract

An improved skin friendly antiperspirant is provided in which a suitable polyhydric alcohol e.g., glycerin, is complexed with the antiperspirant of the type of activated or nonactivated aluminum or aluminum / zirconium salt that are commonly considered antiperspirant active materials and are covered by FDA OTC Tentative Final Monograph as Category I. Suitable antiperspirant salts include (but are not limited to): aluminum chlorohydrate, aluminum sesquichlorohydrate, aluminum chlorohydrex PG, aluminum dichlorohydrex PG, aluminum sesquichlorohydrex PG, aluminum chlorohydrex PEG, aluminum sesquichlorohydrex PEG, aluminum chloride (15 percent or less aqueous solutions), aluminum zirconium chlorohydrates, aluminum zirconium trichlorohydrate, aluminum zirconium tetrachlorohydrate, aluminum zirconium pentachlorohydrate, aluminum zirconium octachlorohydrate, aluminum zirconium trichlorohydrex Gly, aluminum zirconium penta chlorohydrex Gly, aluminum zirconium tetrachlorohydrex Gly, aluminum zirconium octachlorohydrex Gly, buffered aluminum sulfate, basic aluminum chlorides, zirconium hydroxychloride, zirconyl chloride, basic aluminum nitrates, basic aluminum chlorides combined with zirconyl oxychloride and / or hydroxychloride and organic complexes of each of basic aluminum chlorides with or without zirconyl chloride or zirconium hydroxychloride and mixture of any of the foregoing. Aluminum, zinc or zinc and zirconium complexes or aluminum, zinc and zirconium complexes with having metals / anion ratio of 0.9:1 to 2:1 where the anion is Cl, Br, I and / or NO, with or without additives such as amino acids or polyhydric alcohols.

Description

Background of the invention [0001] The present invention relates to a novel skin friendly antiperspirant composition wherein the improved ingredient comprises a polyol, preferably glycerol, which is substantially complexed within the antiperspirant. The present invention is applicable to various types of activated or non-activated aluminum salts or aluminum / zirconium salts, which are recognized active materials in antiperspirants and are approved by the U.S. Food and Drug Administration OTC Interim Final Rule (FDA OTC Tentative Final Monograph) is prescribed as a class I drug. [0002] An ideal antiperspirant product should contribute to skin aesthetics (pleasant skin feel) in addition to good antiperspirant action. The look and feel of the skin is a concern for both consumers and the cosmetic industry. In order to understand how to control the feel and appearance of the skin, it is necessary to have a better understanding of the influence of biological / biophysical factors o...

Claims

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Application Information

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IPC IPC(8): A61K8/20A61K8/26A61K8/28A61K8/34A61K8/44A61Q15/00
CPCA61K8/44A61Q15/00A61K2800/58A61K8/28A61K8/26A61K8/345
Inventor 贾瓦哈·C·帕雷克李子君
Owner RIIHAISU INC
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