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Polyacrylic acid film forming compsn.

A composition, polymer technology, applied in the production of this dosage form, non-gel-forming film-forming coating weight, increased water solubility on dip-coated tablets or caplets, capable of addressing gloss loss, surface roughness, encapsulation Clothes look unsatisfactory, etc.

Inactive Publication Date: 2004-03-10
MCNEIL PPC INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although efforts have been made to improve the rheological properties of these compositions, such as increasing their solids content to increase viscosity, disadvantageously, the coatings formed by these compositions often have an unsatisfactory appearance, such as rough surfaces, decreased gloss, and coating Clothing thickness is uneven

Method used

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  • Polyacrylic acid film forming compsn.
  • Polyacrylic acid film forming compsn.
  • Polyacrylic acid film forming compsn.

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Embodiment 1) prepare dip-coating dispersion liquid

[0073] Aqueous dispersions containing the ingredients listed in Table A were prepared.

[0074] Element

Weight (g)

Available from Rohm Pharma under the trade name "Eudragit RL30D"

Poly(ethyl acrylate, methyl methacrylate), methyl propylene chloride

Trimethylaminoethyl enoate (30% solution) *

100.0

Methylparaben

5.0

Bought from BASF Aktiengesellschaft under the trade name "K-90"

polyvinylpyrrolidone

12.0

water

60.0

Red#55 dye

1.0

Red#40 Lake

0.5

PEG400

4.0

total solution weight

182.5

solids in paint solution

52.5g(28.78％)

[0075] Element

Weight (g)

Available from Rohm Pharma under the trade name "Eudragit RL30D"

Poly(ethyl acrylate, methyl methacrylate), methyl propylene chloride

Trimethylaminoethyl enoate (30% solution) ...

Embodiment 2

[0078] Embodiment 2) preparation secondary coating dispersion liquid

[0079] An aqueous dispersion containing the ingredients listed in Table C was prepared by mixing all ingredients in a beaker under ambient conditions.

[0080] Element

Embodiment 3

[0081] Embodiment 3) prepare dip-coated tablet

[0082] Compressed tablets were prepared according to the method set forth in Example 1 of US Patent No. 5,658,589 ("the '589 patent"), which is incorporated herein by reference.

[0083] The subcoat dispersion of Example 2 was then applied to the above-mentioned tablets by spraying according to the procedure given in the examples of the '589 patent. The weight of the dry tablet with the subcoat was about 4.5% greater than the tablet without the subcoat, ie the amount of the subcoat was about 4.5% of the weight of the uncoated core.

[0084]Half of each of these subcoated tablets was manually dipped into the first dip coating dispersion of Example 1 for a dwell time of 1 second, removed from the dip coating solution, and reapplied under ambient conditions. dry. This process was repeated for each tablet; the other half of each coated tablet was dip-coated in the second dip-coating dispersion of Example 1. The weight gains of th...

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Abstract

Water soluble, gelatin-free dip coatings for substrates comprising an acrylic film former; a paraben plasticizer; and a secondary plasticizer such as polyvinylpyrrolidone, polyethylene glycol 300, polyethylene glycol 400 or mixtures thereof.

Description

field of invention [0001] The present invention relates to novel water-soluble, gelatin-free compositions useful for coating substrates such as tablets, capsules, etc., and methods of producing such pharmaceutical forms. The present invention also relates to a method of increasing the weight of a water-soluble, gel-free, film-forming coating on a dip-coated tablet or caplet. Background of the invention [0002] For most of this century, hard gelatin capsules were the common dosage form for prescription and over-the-counter (OTC) medications. The ability to combine capsule halves of different colors provides manufacturers with a unique means of differentiating various pharmaceutical products. Many patients prefer capsules to tablets, finding them easier to swallow. This consumer preference has prompted pharmaceutical manufacturers to market certain products in capsule form, even though these products are also available in tablet form. [0003] Empty hard gelatin capsules a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/32A61J3/00A61K9/20A61K9/28A61K9/32A61K9/48A61K9/58A61K47/14A61K47/34
CPCA61K9/2072A61K9/2846A61K9/4816A61J3/00
Inventor S·卡马特
Owner MCNEIL PPC INC
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