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Valerian extract and its preparation method and use

A technology of extracts and plant extracts, which is applied in the field of medical or health care, and can solve the problem of many impurities in the extract

Inactive Publication Date: 2004-02-18
曹凯
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent CN1337255A is a kind of preparation method of valerian root extract, which only adopts the traditional ethanol percolation method, and there are many impurities in the extract

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Take 500g of Valeriana valeriana and grind it into coarse powder, pass through a 20 mesh sieve, put it in an extraction kettle for extraction, the extraction pressure is 25Mpa, and then heat it to the extraction temperature of 50°C through a heat exchanger, the extraction time is 6h, and the extracted The supercritical CO2 of the product enters the separation kettle through a pressure reducing valve and carries out analysis and separation. The analysis pressure is 7.0Mpa, the analysis temperature is 30°C, and the analysis time is 4h to obtain 20ml of valerian root volatile oil.

[0015] Soak the extracted medicinal residues with 8 times the amount of 85% ethanol solution for 6 hours, add ethanol for percolation, and use high performance liquid chromatography to detect that there is no valerian in the percolation liquid, collect the percolation liquid, and recover under reduced pressure Ethanol, concentrating the percolation liquid to 2 times the weight of the medicinal m...

Embodiment 2

[0017] A solid formulation containing valerian extract was prepared.

[0018] Its preparation method is to mix valerian root extract and pharmaceutical auxiliary materials including excipients, fillers, disintegrating agents, coating agents, slow-release agents, co-solvents, dispersants, preservatives, etc., and granulate. The pharmaceutical process is made into tablets, capsules, soft capsules, sustained-release tablets, sustained-release capsules, pellets, etc.

Embodiment 3

[0020] Preparation of valerian extract water injection, powder injection, transfusion and fat emulsion injection.

[0021] (1) To prepare water injection of valerian extract, add 30 g of valerian extract to 1 L of aqueous solution for injection containing Tween 80, adjust the pH of the solution to 5.0-7.0, and add water for injection after microporous membrane ultrafiltration Replenish to the specified amount, pack in ampoules, each 2ml, melt seal, and pack after passing the inspection.

[0022] (2) To prepare valerian extract infusion, add 10 g of valerian extract to 1 L of aqueous solution for injection containing Tween 80, adjust the pH of the solution to 5.0-7.0, and add water for injection after microporous membrane ultrafiltration Replenish to the specified amount, pack in corresponding infusion bottles of 100ml, 150ml, and 200ml, crimp the caps, and pack after passing the inspection.

[0023] (3) To prepare valerian extract powder injection, dissolve the valerian extra...

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PUM

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Abstract

A valerian extract with calming and anti-spasm activity, its medicines for treating the spasm of cardiac blood vessel, respiratory tract and enterogastric tract and increasing the acidity of gall, and its preparing process are disclosed. Said extract contains valerian oil and valerianine (10-90%).

Description

technical field [0001] The invention relates to a valerian extract with sedative and antispasmodic activity and a pharmaceutical preparation containing the extract, and also includes a preparation method and medical or health care application of the extract. Background technique [0002] Valerian is a perennial herbaceous plant belonging to the genus Valeriana in the family Patracaceae. It mainly contains monoterpenes (iridoids), sesquiterpenes, alkaloids, lignans, flavonoids and other components. It is a mild sedative , has a good sleep-improving effect, and its functions also include safely relieving tension, anxiety, hyperactivity and being used as a blood pressure lowering, antispasmodic and nerve relaxant. Valerian sencha has been drunk among European folks for at least hundreds of years to help them fall asleep. [0003] People are more and more worried about the drug dependence and addiction of some commonly used synthetic drugs such as 2,3 benzodiazepines (benzodiaz...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/105A61K31/351A61P25/20C07D493/10
Inventor 曹凯
Owner 曹凯
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