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Convenient fibrin blocking agent

A technology of fibrin and fibrinogen, which is applied in the field of medical preparations, can solve the problems of difficult reconstitution of fibrinogen concentrate, delay in rescue time, unfavorable surgical operation, etc., and achieve shortened surgical operation process, simple and convenient operation, and simplified The effect of the procedure

Inactive Publication Date: 2003-11-12
徐振彪
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use process of FS is very cumbersome, and the operation is quite troublesome (see FS products and instructions)
This not only brings inconvenience to use, but also delays the rescue time sometimes.
In particular, fibrinogen concentrate, one of the components of the product, is very difficult to reconstitute, and its dissolution time is generally 30-60 minutes, which is often not conducive to the doctor's operation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] The coagulable protein concentrate in the present invention mainly refers to fibrinogen, factor XIII (FXIII), etc., which can activate coagulation in blood under the catalysis of corresponding coagulation factors. The coagulable protein concentrate in the invention can be derived from human blood or any mammalian blood such as pig, cow and so on. The coagulable protein can be separated by any method known to those skilled in the art, such as: cryoprecipitation, ethanol precipitation, chromatographic separation, salting out, etc., any known and mature method to separate and purify coagulable protein in blood Methods. Prepare raw materials according to the ratio of 60-100mg / ml fibrinogen, 30-60U / ml factor XIII, and 200-600IU / ml thrombin. The fibrinogen and factor XIII are in the same component, also known as coagulable protein concentrate, and the concentration should reach 80-150mg / ml. Mix fibrinogen and factor XIII into a coagulable protein concentrate, dissolve the c...

Embodiment 2

[0012] Prepare raw materials according to the ratio of 80 mg / ml fibrinogen, 50 U / ml factor XIII, and 400 IU / ml thrombin. The fibrinogen and factor XIII are in the same component, also known as coagulable protein concentrate, and the concentration should reach 80-150mg / ml. Mix fibrinogen and factor XIII into a coagulable protein concentrate, dissolve the coagulable protein concentrate and prothrombin complex with phosphate buffer and Tris-Hcl buffer respectively, adjust the pH to 6-8, and then Sterilized by filtration, concentrated by ultrafiltration, and then aseptically filled.

Embodiment 3

[0014] Prepare raw materials according to the ratio of 60-100mg / ml fibrinogen, 30-60U / ml factor XIII, and 200-600IU / ml thrombin. The fibrinogen and factor XIII are in the same component, also known as coagulable protein concentrate, and the concentration should reach 80-150mg / ml. Mix fibrinogen and factor XIII into a coagulable protein concentrate, dissolve the coagulable protein concentrate and prothrombin complex with phosphate buffer and Tris-Hcl buffer respectively, adjust the pH to 6-8, and then Sterilize by filtration, concentrate by ultrafiltration, freeze-dry into blocks by any method that can be freeze-dried, and then crush the freeze-dried blocks into fine powder particles by any method that can be crushed, and sieve to make the crushed The diameter of the particles is between 50-500 microns, and then they are divided into vials.

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Abstract

The invention provides a convenient sealing agent for fibrin. It is made up of fibrin source 60-100 mg / ml, factor XIII (FXIII) 30-60 U / ml, thrombin 200-600 IU / ml and the buffer, the PH value is 6-8. the invention has rheology character, and strong adhesive ability, imitates the final period of physical cruor mechanism. It exerts functions of biological hemostasis, promotes the concrescence of wound, prevents organism conglutination, conglutinates viscera gap, seals lacuna organism in order to decrease the exudation, medicine releasing carrier slowly. It applies to all the modern surgical.

Description

[0001] (1) Fields [0002] The present invention relates to a medical preparation, specifically a medical preparation for hemostasis in operation, promotion of wound healing and the like. (two), background technology [0003] Wound healing and bleeding are not only problems faced by modern surgical operations, but also bring life-threatening risks to patients if they are not treated in time or properly. After years of research, scientists have developed a "human glue", the main components of which are fibrinogen and thrombin. Although there are various names, as long as the main ingredients and the principle of action are basically the same, it is the same product. The following is represented by fibrin sealant (Fibrin sealant, FS). This product works by simulating the final stage of the human body's own blood coagulation process, and its ingredients are pure natural proteins, so the toxicity and side effects during use are minimized. The composition and instructions of thi...

Claims

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Application Information

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IPC IPC(8): A61K9/19A61K38/48A61P7/04A61P41/00
Inventor 徐振彪宋林霞
Owner 徐振彪
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