Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Porous synthetic bone graft and method of manufacture thereof

A technology of artificial bone and porous structure, applied in the field of artificial bone, which can solve the problems that nutrients cannot flow through the artificial porous graft bone, and the graft bone is not suitable for large-scale applications, etc.

Inactive Publication Date: 2003-10-01
ORTHOGEM LTD
View PDF0 Cites 14 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although most commercially available bone grafts have a similar chemical composition to the minerals of living bone, they are not suitable for large-scale use or as a permanent replacement because nutrients cannot flow through the artificial pores after surgery bone graft

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Porous synthetic bone graft and method of manufacture thereof
  • Porous synthetic bone graft and method of manufacture thereof
  • Porous synthetic bone graft and method of manufacture thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Commercially available medical grade hydroxyapatite Ca with a particle size of 0.6–1 μm was used 10 (PO 4 ) 6 (OH) 2 Powder (ASTMF118588) to produce artificial porous bone graft. The first step is to prepare a slurry consisting of:

[0053] 160g hydroxyapatite powder

[0054] 70ml deionized water

[0055] 2 g ammonium polyacrylate

[0056] The ingredients are first mixed uniformly in a plastic container with a spatula. When a homogeneous solution had formed, mechanical agitation was performed at approximately 1200 rpm for 5 minutes with a double blade stirrer. This made approximately 115ml of slurry. The slurry is then poured into a drum mill to further disperse the clot; this is a polyethylene flask, 10 cm long and 6 cm in diameter, containing a 100 cm 3 high density small Al 2 o 3 cylinder. The drum mill was sealed and turned at 120 rpm for 30 minutes to form a homogeneous slurry.

[0057] 70 grams of finely sifted wheat flour and 7 grams of yeast cells w...

Embodiment 2

[0067] A sample of the porous HA article obtained in Example 1B was immersed in a boiling HA slurry with an average particle size of 0.2 μm. Immersion times ranged from 30 minutes to 90 minutes with 30 minute intervals and the slurry was constantly agitated. Afterwards, the excess slurry was removed through a centrifugation process (at a speed of 2500-15000 rpm). These samples were then annealed at 1280°C for 5 hours.

[0068] The samples were mechanically tested using a Lloyd benchtop testing machine equipped with a 2.5KN force gauge and computer remote control. The load was applied to these specimens by a crosshead speed of 0.1 mm per minute (average specimen contact area of ​​0.8 cm 2 ) until a brittle break occurs. exist figure 2 The obtained results are shown in . It can be seen that the compressive strength of the porous HA specimen increases with the immersion time.

Embodiment 3

[0070] 6 grams of PCL were melted in a 150cc glass beaker by placing in a 60°C furnace. After the solid PCL had melted into a clear viscous fluid, 20ml of acetone was added to dissolve the PC1 and form a liquid solution. The viscosity of the solution is 0.8835±0.025pas. The porous sample of Example IB was then immersed in the solution and kept boiling by placing it on a hot plate at a constant temperature of 57°C.

[0071] After 20 minutes, the samples were removed and subjected to a centrifugation process (speed 2500-15000 rpm) to remove any excess solution from the interconnected macroporous structure. These samples were then placed in an oven at 60°C to melt any blocked PCL in the macroporous structure, and the centrifugation process was repeated.

[0072] The mechanical tests of Example 2 were carried out. The results obtained are as in image 3 as shown in. It can be seen that the PCL reinforced HA samples have significantly enhanced compressive strength.

[0073] ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A process for preparing artificial bone is described which comprises: (i) preparing a mixture of a finely divided bio-compatible ceramic powder, an organic binder and a pore-forming agent in an inert liquid to form a body and causing at least some of the pore-forming agent to align along a common axis; (ii) optionally shaping the resulting body; (iii) allowing the pore-forming agent to form a porous structure in the body; (iv) heating the shaped body to a temperature sufficient to fix the porous structure and; (v) further heating the body to eliminate residues of organic binder and pore-forming agent and to fuse it.

Description

[0001] The present invention relates to a method of constructing artificial bone in the form of a porous block from calcium phosphate or other ceramic powders. More specifically, the present invention relates to a novel fabrication method for forming superior artificial bone grafts with controlled porosity. It can be used to replace autografts and allografts used in orthopedic procedures including vertebral restoration, musculoskeletal reconstruction, fracture repair, hip and knee reconstruction, bone strengthening procedures and / or oral / maxillofacial procedures graft. [0002] The current European bone graft market is dominated by autografts (bone taken from one part of the body and transferred to another part of the same person) and allografts (bone taken from one person and transferred to a different person). During an autograft, the bone graft is usually extracted from the pelvis of the patient's body. Both operations must be performed at the same time. The patient benefi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/00A61F2/00A61F2/02A61F2/28A61F2/30A61F2/46A61L27/12C04B38/02C04B38/06
CPCA61F2/28A61F2/4644A61F2002/2817A61F2002/2835A61F2002/30062A61F2002/30957A61F2210/0004A61F2310/00293A61L27/12A61L2430/02C04B35/447C04B35/6261C04B35/63424C04B35/636C04B38/02C04B38/062C04B2111/00836C04B2235/3212C04B2235/5445C04B2235/6021C04B2235/606C04B2235/6562C04B2235/6565C04B2235/96C04B41/0072C04B41/45C04B41/5025C04B22/106C04B40/0683C04B22/16C04B2103/0001
Inventor 罗伟仁
Owner ORTHOGEM LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com