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Biological active bone tissue inducing regeneration film and preparation method

A technology of biological activity and bioactive factors, applied in the field of medical materials and their preparation, can solve the problems of no tissue induction, achieve huge social and economic benefits, be easy to control, and have a wide range of applications

Inactive Publication Date: 2003-08-27
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These two types of membranes, like foreign products, only have the basic properties of medical membranes, and also do not have tissue induction.

Method used

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  • Biological active bone tissue inducing regeneration film and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Weigh 2 grams of polylactic acid with a viscosity of 3.51 with a balance, add it to 40ml of ethyl acetate, and swell at room temperature for 12 hours, stir and dissolve for 1 hour, and after defoaming for 1 hour, pour it into a 10×10cm flat mold. What this embodiment chooses is flat flow casting film on flat glass mold, then put it into a semi-closed container to slowly volatilize ethyl acetate for 1 day, then open and volatilize for 2 days, then vacuum dry at 70°C for 8 hours to remove residual of ethyl acetate.

[0025] Under the condition that the prepared polylactic acid membrane is separated from the surrounding membrane without demolding, use a probe to scratch and roughen the surface to form staggered scratches with a depth of 1 to 10 microns, and then place the cow 0.5 g of collagen was dissolved in 0.01M acetic acid and made into a 3% collagen solution, which was evenly spread on the scratched membrane surface, and then evaporated and dried naturally at room te...

Embodiment 2

[0029] Use a balance to weigh 3 grams of polylactic acid with a viscosity of 3.32, add it to 50ml of ethyl acetate, and swell at room temperature for 15 hours, stir and dissolve for 2 hours, and after defoaming for 1 hour, pour it into a 14×14cm flat mold. What this embodiment chooses is flat flow casting film on flat glass mold, then put into semi-closed container and volatilize ethyl acetate slowly for 2 days, then open and volatilize for 1 day, then vacuum dry at 60°C for 6 hours to remove residual of ethyl acetate.

[0030] Under the condition that the prepared polylactic acid membrane is separated from the surrounding membrane without demoulding, use a probe to scratch and roughen the surface to form staggered scratches with a depth of 1 to 10 microns, and then place the pig 1.0 g of collagen was dissolved in 0.01M acetic acid and made into a 1% collagen solution, which was evenly spread on the scratched membrane surface, and then evaporated and dried naturally at room te...

Embodiment 3

[0034] Use a balance to weigh 3 grams of polylactic acid with a viscosity of 3.78, add it to 100ml of ethyl acetate, and swell at room temperature for 18 hours, stir and dissolve for 2 hours, and after defoaming for 2 hours, pour it into a 14×14cm flat mold. What this embodiment chooses is flat flow casting film on flat glass mold, then put into semi-closed container and volatilize ethyl acetate slowly for 2 days, then open and volatilize for 2 days, then vacuum dry at 80°C for 10 hours to remove residual of ethyl acetate.

[0035] Under the condition that the prepared polylactic acid membrane is separated from the surrounding membrane without demolding, use a probe to scratch and roughen the surface to form staggered scratches with a depth of 1 to 10 microns, and then place the cow 1.0 g of collagen was dissolved in 0.01M acetic acid and made into a 2% collagen solution, evenly spread on the scratched membrane surface, and allowed to evaporate and dry naturally at room temper...

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Abstract

The present invention discloses a bioactive bone tissue induced regeneration membrane, which has two-layer composite structure, one layer is polylactic acid, and another layer is a mixture of cololagen fibre and bioactive factor recombinant human gene bone morphogenetic protein. Said membrane is made up by the steps: on the polylactic acid base membrane made up by swelling, stirring, dissolving, defoaming and moulding, making scratching and roughening treatment, coating collagen fibre solution, then coating collagen fibre and bioactive factor recombinant human gene bone morphogenetic protein mixed solution, cooling and vacuum drying. Said membrane has has the bone induced activity, can make the damaged region of bone grow new bone again.

Description

1. Technical field [0001] The invention belongs to the technical field of medical materials and preparation methods thereof, and in particular relates to a medical biofilm material capable of inducing bone tissue regeneration and a preparation method thereof. 2. Background technology [0002] Clinically, tissue defects caused by various reasons are very common. In order to provide regeneration space for the self-repair of the defective tissue and achieve the purpose of morphological and functional reconstruction, a bio-diaphragm is usually installed between the defective tissue site and other tissues in clinical practice. Generally speaking, in addition to functioning as a barrier between different tissues, the biomembrane used in the body also requires good compatibility and the ability to degrade in vivo. However, with the continuous development of medical material technology and the improvement of clinical use requirements, people also hope to obtain a diaphragm with tiss...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/12A61L31/16
Inventor 田卫东包崇云李声伟刘磊
Owner SICHUAN UNIV
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