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Biological material using electrostatic attraction layer-layer self-assembled modified polyester material as surface with cell compatibility

A technology of layer-by-layer self-assembly and modification of polyester, applied in the fields of nanotechnology, nanomedicine, medical science, etc. for materials and surface science, can solve the inflammatory response of surrounding organs and tissues, unsuitable scaffold materials and products, Can not provide tissues and organs and other problems to achieve the effect of reducing inflammation, improving cytocompatibility, and good application prospects

Inactive Publication Date: 2003-02-05
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to its own hydrophobicity and surface inertness, unmodified polyester polymers cannot provide a friendly interface to effectively promote the growth of tissues and organs; the local acidity formed after degradation will also cause damage to surrounding organs and tissues. severe inflammatory reaction
Although there are many surface modification methods to improve their surface properties, they all have problems such as complicated operation process and poor stability of the modified surface, especially not suitable for porous scaffold materials and products with complex shapes.

Method used

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  • Biological material using electrostatic attraction layer-layer self-assembled modified polyester material as surface with cell compatibility
  • Biological material using electrostatic attraction layer-layer self-assembled modified polyester material as surface with cell compatibility
  • Biological material using electrostatic attraction layer-layer self-assembled modified polyester material as surface with cell compatibility

Examples

Experimental program
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Effect test

example 1

[0031] Poly(L-lactic acid) was dissolved in 1,4-dioxane (the polylactic acid content was 3% by weight), and cast in a film-forming mold to form a film. The poly(L-lactic acid) membrane was immersed in a 1,6-hexanediamine / n-propanol solution with a concentration of 0.06 g / mL, reacted at 50°C for 8 minutes, soaked and cleaned with deionized water, and dried under vacuum. Take a small piece of membrane in a ninhydrin solution with a concentration of 1.0mol / L, and detect the presence of free amine groups (-NH 2 ).

[0032] The above-mentioned poly(L-lactic acid) film with free amine groups on its surface was immersed in hydrochloric acid with a concentration of 0.012mol / L for acidification for 15 minutes, taken out and rinsed with triple distilled water, then immersed in 1.0 mg / ml sodium polystyrene sulfonate ( PSS) solution for 20 minutes, rinsed with triple distilled water and blown dry with nitrogen, then soaked in 1.0mg / ml chitosan acetic acid solution for 15 minutes, rinsed ...

example 2

[0035] The polyester polyurethane was dissolved in N,N-dimethylformamide to make the concentration of the polymer solution reach 0.13 g / mL, and the solution was cast in a film-forming mold to form a film. The polyester polyurethane film was immersed in 1,6-hexanediamine / n-propanol solution with a concentration of 0.06 g / ml, reacted at 37° C. for 5 minutes, rinsed with triple distilled water, and vacuum-dried to constant weight. Take a 2 cm long and 1 cm wide aminolytic polyester polyurethane, soak it in ninhydrin / absolute ethanol solution with a concentration of 1.0mol / L for 1 minute, take it out, and heat it at 80°C, the surface of the film shows obvious blue-purple, indicating the presence of free amine groups (-NH 2 ). Immerse the above-mentioned polyester polyurethane film with free amine groups on its surface into hydrochloric acid with a concentration of 0.012mol / l to acidify for 15 minutes, take it out and rinse it with triple distilled water, and then add it to hepari...

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Abstract

Fistly, said ivnention utilizes polyamine aminolyzed polyester polymer surface to obtain polymer whose surface has free amine group, then uses acid to make acidification to make polymer surface possess positive charge, and utilzies electrostatic attraction layer-to-layer self-assembling method to alternatively assemble single layer or several layers of different polyanions and polycations with biological activity on its surface, and these biological activity polyelectrolytes which are layer-to-layer self-assembled still retain their original biological activity so as to obtain the invented plane membrane and three-D porous support material with cell compatibility and its product.

Description

technical field [0001] The invention relates to a method for modifying polyester materials into biomaterials with cell compatibility on the surface. Specifically, it uses polyamines to amine and then electrostatically attracts layer-by-layer self-assembled polyelectrolytes with biological activity to prepare the surface. A method for cytocompatible polyester-based biomaterials. Background technique [0002] Due to their excellent physical and chemical properties, polymer biomaterials are more and more widely used in tissue engineering. However, due to the special application environment of this type of material - it needs to be in direct contact with body fluids, organs, tissues, etc. one. [0003] Polyester biomaterials not only have good physical and mechanical properties, non-toxicity, easy processing and molding, but also have biodegradability unique to tissue engineering materials, so they have attracted more and more attention. Polyester po...

Claims

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Application Information

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IPC IPC(8): A61L27/44A61L27/58C08J7/12
CPCB82Y5/00B82Y30/00
Inventor 高长有竺亚斌沈家骢
Owner ZHEJIANG UNIV
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