Application of niflumic acid in preventing and treating arrhythmia
A technology of niflufenamic acid and niflufenamic acid, which is applied in niflumic acid, a known drug field, and can solve problems such as adverse side effects
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[0042] The present invention will be further described in detail below in conjunction with the accompanying drawings.
[0043] In the isolated rat heart perfusion experiment, the applicant found that NFA has the following effects in addition to the known effects:
[0044](1) Slow down the heart rate and weaken the contractility of the heart: 25 μmol / L niflufenamic acid weakens the left ventricular contractility and slows the heart rate of the isolated perfused rat heart (see figure 1 ), this effect was dose-dependent, the half effective dose (EC 50 ) is about 44μmol / L (see Image 6 ). Niflumic acid can inhibit ventricular muscle contraction and slow heart rate.
[0045] (2) Anti-hypotonic arrhythmia effect: hypotonic perfusate (osmotic pressure is 25% lower than that of isotonic fluid) can significantly enhance the contractility of ventricular muscle and induce arrhythmia; 25 μmol / L niflumic acid can make Rapid termination of hypotonic arrhythmias (see figure 2 ); pre-ad...
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