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Liver-protecting detoxification particles for curing drug induced liver injury and its production method

A technology for protecting liver, detoxifying and treating drugs. It is used in drug combinations, pharmaceutical formulations, plant raw materials, etc., and can solve problems such as damage, dose irrelevance, and complexity.

Inactive Publication Date: 2007-07-11
彭勃 +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The pathogenesis of DILI varies from drug to drug, is very complex, and in most cases remains unclear
Some drugs have direct toxic effects, and the liver damage caused by them is generally predictable, and the damage is related to the drug and is specific to some drugs; other drugs only occasionally cause liver damage in sensitive individuals and are independent of dose , it is difficult to predict whether it will occur or not

Method used

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Embodiment Construction

[0006] The specific implementation manners of the present invention will be described in detail below in combination with actual conditions.

[0007] Given by the prescription, the present invention is made by weight: aloe 35-45%, tribulus terrestris 15-25% and jujube 35-45%, and it is preferably made by weight: aloe 40% 20% of Tribulus terrestris and 40% of Chinese jujube, specifically, one dose is made of 30g of aloe, 15g of Tribulus terrestris and 30g of Chinese jujube; the production method of liver-protecting and detoxifying granules for the above-mentioned treatment of drug-induced liver injury Yes, first extract aloe vera, tribulus terrestris and jujube polysaccharide respectively to obtain aloe polysaccharide, total saponins of tribulus terrestris and jujube polysaccharide; 35-45% mixed together, 15g finished medicine is equivalent to crude drug 52.5g, is made into granule with granulator, and said aloe polysaccharide is cut into pieces by fresh aloe leaf (8kg), decoct...

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Abstract

Disclosed are liver-protecting detoxification particles for treating drug-induced liver injury and its production method, which consists of extracting aloe polysaccharides, Tribulus terrestris saponins and date polysaccharides, then mixing and producing granules by the proportion of the original medicament.

Description

1. Technical field [0001] The invention relates to liver-protecting and detoxifying granules for treating drug-induced liver injury. 2. Background technology [0002] Drug-induced Liver Injury (DILI for short) refers to the liver damage caused by the toxic effect of drugs or their metabolites, or the body's allergic reaction to drugs. With the wide application of chemically synthesized drugs, DILI has become a common clinical factor leading to liver injury. In Western countries, 2% of hospitalized jaundice patients are caused by drugs, and about 1 / 4 of fulminant liver failure is related to drugs. Domestic literature reports that the incidence of DILI accounts for about 1 / 600---1 / 3500 of hospitalized patients. Common drugs that cause DILI include antibiotics, anti-tuberculosis drugs, antineoplastic drugs, cardiovascular drugs, and some Chinese herbal medicines. [0003] The susceptibility to DILI is related to factors such as age, sex, genetic polymorphisms of drug biotran...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/896A61K36/725A61K36/185A61K9/16A61P1/16
Inventor 彭勃苗明三禄保平杨晓娜彭成
Owner 彭勃
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