Improved method of preparing secnidazole
A kind of technology of other butnidazole and nitro group is applied in the field of preparing other butnidazole-2-methyl-5-nitro-1H-imidazole), can solve problems such as low yield, and achieve the effect of less consumption
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[0030] 2-Dimethyl-5-nitro-1H-imidazole-1-ethanol (i.e. another butinidazole, also known as 1-(2-hydroxypropyl)-2-methyl-5-nitro-1H-imidazole ) preparation method
[0031] In a 5-liter four-necked flask with a cooling device and a dropping funnel with a jacket, add 1600ml of anhydrous ethyl acetate, cool to 0-5 degrees Celsius under stirring, and slowly add 400g (3.0mol) of anhydrous chlorinated Aluminum, keep the temperature between 0-5 degrees Celsius. To the resulting clear solution was added 200 g (1.5748 mol) of 2-methyl-5-nitro-imidazole. Observe for a thick slurry. Keep the temperature at 0-5 degrees Celsius, add 160 g (2.75 mol) of propylene oxide dropwise, and control the dropping rate at about 1 hour. The reactant was continuously stirred for 3 hours at a temperature of 0-5 degrees Celsius, then poured into diluted hydrochloric acid, and stirred for 15 minutes. The reaction solution was filtered to remove unreacted 2-methyl-5-nitro-imidazole. Dry at -80°C for 24 ...
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