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Aromatase inhibitor

A technology of aromatase and inhibitors, applied to medical preparations containing active ingredients, organic active ingredients, diseases, etc., to achieve simple and convenient operation, great economic value, and remarkable effects

Inactive Publication Date: 2006-09-06
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, letrozole is mainly used to treat breast cancer in women, but there is no report on the sex control of fish

Method used

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Examples

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Embodiment 1

[0015] 40 2-year-old grouper, weighing 0.6-1Kg, were purchased from fishing raft cages in the waters near Daya Bay, Guangdong Province, and temporarily kept in fishing raft cages (5*5*3m) of Daya Bay Aquatic Products Experimental Center. After 2 weeks of temporary breeding, the grouper was randomly divided into two groups, 20 in each group, and raised in two cages, one of which was the letrozole group, and the other was the blank control group. The experiment was carried out from May to August in 2003, with an average water temperature of 26.5-29.6°C.

[0016] The feeding method is as follows: beat chilled fish into fish paste, then add appropriate proportion of compound bait, high-quality fish oil, and water to make bait. The blank control group was only fed bait, and the letrozole group was added letrozole to the bait at a rate of 2 mg letrozole per kilogram of bait. Feed 2 times a day regularly, the amount of bait fed is about 5% of the fish's body weight, and the uneaten ...

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Abstract

Disclosed is an aromatase inhibitor which is a key enzyme for catalyzing the conversion from androgen to estrogen in animal body, by inhibiting activity of aromatized enzyme, the level of estrogen can be lowered, so as to evoke the animal towards male direction. The invention can be applied to the inducement of sex inversion in advance for Epinephelus coioides with the advantages of easy operation, substantial effects, and no hormones contamination to the environment.

Description

technical field [0001] The invention relates to the field of animal sex research, in particular to the application of letrozole as an aromatase inhibitor in inducing premature sex reversal of grouper. Background technique [0002] Slanted grouper (Epinephelus coioides) belongs to the order Perciformes, the family Apiidae, the subfamily of groupers, and the genus Grouper. Its meat is delicious and nutritious, and it is the first-class delicacy on the dining table. It grows fast, and the market price is high and stable, and it is an important economic fish for marine aquaculture in coastal areas of my country. The oblique-banded grouper is a kind of hermaphroditic fish that is pre-feminine. It is female at first, and sex reversal occurs when the body length is 500-750mm. The male needs to be about 6 years old to mature, and it is often difficult to obtain simultaneously during artificial reproduction. The problem of functional male and female broodstock makes seed production...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4196A61P15/00
Inventor 张为民张勇张利红林浩然
Owner SUN YAT SEN UNIV
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