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Ophthalmic solution

A technology of eye drops and medicinal salts, which is applied in the direction of drug combination, cardiovascular system diseases, active ingredients of heterocyclic compounds, etc., and can solve problems such as inability to eliminate congestion

Inactive Publication Date: 2006-08-23
SENJU PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, hyperemia of the cornea with severe hyperemia of the pericorneal area is caused by inflammation in the cornea, sclera, and uvea, and instillation of vasoconstrictors does not resolve the hyperemia

Method used

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Examples

Experimental program
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Effect test

preparation example Construction

[0037] The ophthalmic solution of the present invention can be prepared according to per se known production methods, for example, the methods described in Japanese Pharmacopoeia Thirteenth Edition, Formulation Routine. For example, buffers, isotonic agents, preservatives and other additives are dissolved in water, then the vasoconstrictor and pranoprofen are dissolved and sterilized to produce the eye drops of the present invention.

[0038] Depending on the dosage form of the enhancer, the enhancer of the present invention can be produced according to per se known production methods. For example, the enhancer can be produced in accordance with the method described in Japanese Pharmacopoeia Thirteenth Edition, Formulation General.

[0039] The present invention further provides a method for improving hyperemia in the outer ocular region, which comprises administering to a patient an effective amount of pranoprofen or a pharmaceutically acceptable salt thereof, and an effectiv...

Embodiment 1

[0054] Pranoprofen 0.05g

[0055] Tetrahydrozoline hydrochloride 0.05g

[0056] Boric acid 1.6g

[0057] Appropriate amount of borax

[0058] Benzalkonium Chloride 0.005g

[0059] Polysorbate 80 0.1g

[0060] Add sterile purified water to 100ml

[0061] Polysorbate 80, boric acid, tetrahydrozoline hydrochloride, pranoprofen and benzalkonium chloride were completely dissolved in sterile purified water (ca.70ml), and the pH was adjusted to 7.0 with borax, and then added without Bacteria purified water to a total volume of 100ml. The solution is sterilized by filtration and filled in containers suitable for eye drops.

Embodiment 2

[0063] Pranoprofen 0.05g

[0064] Phenylephrine Hydrochloride 0.1g

[0065] Sodium dihydrogen phosphate 0.2g

[0066] Sodium chloride 0.8g

[0067] Benzalkonium Chloride 0.005g

[0068] Polysorbate 80 0.1g

[0069] Appropriate amount of sodium hydroxide

[0070] Add sterile purified water to 100ml

[0071] Completely dissolve polysorbate 80, sodium dihydrogen phosphate, sodium chloride, phenylephrine hydrochloride, pranoprofen and benzalkonium chloride in sterile purified water (ca. Adjust the pH to 7.5 with sodium, then add sterile purified water to a total volume of 100 ml. The solution is sterilized by filtration and filled in containers suitable for eye drops.

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PUM

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Abstract

The present invention provides an ophthalmic solution containing pranoprofen or a pharmacologically acceptable salt thereof, and a vasoconstrictor, which is effective for ameliorating congestion in outer ocular areas, particularly conjunctiva and pericorneal area.

Description

technical field [0001] The present invention relates to an eye drop that eliminates or relieves hyperemia in the outer ocular area, particularly the conjunctival and pericorneal areas. Background technique [0002] Due to physical or chemical stimuli, such as light, burns, smoke, chemical vapors, etc., the bulbar conjunctiva (white of the eye) is easily congested. In addition, blepharitis, conjunctivitis, etc. also cause congestion. To relieve these congestions, commercially available eye drops containing vasoconstrictors are used, which provide a temporary effect. However, hyperemia of the cornea with severe hyperemia of the pericorneal area is caused by inflammation in the cornea, sclera, and uvea, and instillation of vasoconstrictors does not resolve the hyperemia. Even eye drops containing anti-inflammatory drugs such as allantoin, dipotassium glycyrrhizinate, etc., and vasoconstrictor drugs such as naphazoline hydrochloride are not enough to eliminate or relieve the c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/436A61K31/4164A61K31/137A61K9/08A61K45/00A61P9/08A61P27/14C07D491/052A61K9/00A61K31/44A61K45/06
CPCA61K45/06A61K9/0048A61K31/44A61K31/436A61K31/137A61K31/4164A61P27/02A61P27/14A61P43/00A61P9/08A61K31/00A61K2300/00
Inventor 中山久幸西畑秀一安艺博
Owner SENJU PHARMA CO LTD
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