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Ophthalmic solution

An eye drop, vasoconstriction technology, which can be used in drug combinations, cardiovascular system diseases, active ingredients of heterocyclic compounds, etc., can solve problems such as inability to eliminate congestion

Inactive Publication Date: 2003-08-27
SENJU PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, hyperemia of the cornea with severe hyperemia of the pericorneal area is caused by inflammation in the cornea, sclera, and uvea, and instillation of vasoconstrictors does not resolve the hyperemia

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Pranoprofen 0.05g

[0088] Tetrahydrozoline hydrochloride 0.05g

[0089] Boric acid 1.6g

[0090] Appropriate amount of borax

[0091] Benzalkonium Chloride 0.005g

[0092] Polysorbate 80 0.1g

[0093] Add sterile purified water to 100ml

[0094] Polysorbate 80, boric acid, tetrahydrozoline hydrochloride, pranoprofen and benzalkonium chloride were completely dissolved in sterile purified water (ca.70ml), and the pH was adjusted to 7.0 with borax, and then added without Bacteria purified water to a total volume of 100ml. The solution is sterilized by filtration and filled in containers suitable for eye drops.

Embodiment 2

[0096] Pranoprofen 0.05g

[0097] Phenylephrine Hydrochloride 0.1g

[0098] Sodium dihydrogen phosphate 0.2g

[0099] Sodium chloride 0.8g

[0100] Benzalkonium Chloride 0.005g

[0101] Polysorbate 80 0.1g

[0102] Appropriate amount of sodium hydroxide

[0103] Add sterile purified water to 100ml

[0104]Completely dissolve polysorbate 80, sodium dihydrogen phosphate, sodium chloride, phenylephrine hydrochloride, pranoprofen and benzalkonium chloride in sterile purified water (ca. Adjust the pH to 7.5 with sodium, then add sterile purified water to a total volume of 100 ml. The solution is sterilized by filtration and filled in containers suitable for eye drops.

Embodiment 3

[0106] Pranoprofen 0.05g

[0107] Naphazoline hydrochloride 0.003g

[0108] Sodium chloride 0.8g

[0109] Citric acid 0.2g

[0110] Appropriate amount of borax

[0111] Benzalkonium Chloride 0.005g

[0112] Polysorbate 80 0.1g

[0113] Add sterile purified water to 100ml

[0114] Dissolve polysorbate 80, citric acid, sodium chloride, naphazoline hydrochloride, pranoprofen and benzalkonium chloride completely in sterile purified water (ca. 70ml), and adjust the pH to 7.8 with borax , and then add sterile purified water to a total volume of 100ml. The solution is sterilized by filtration and filled in containers suitable for eye drops.

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PUM

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Abstract

The present invention provides an ophthalmic solution containing pranoprofen or a pharmacologically acceptable salt thereof, and a vasoconstrictor, which is effective for ameliorating congestion in outer ocular areas, particularly conjunctiva and pericorneal area.

Description

technical field [0001] The present invention relates to an eye drop that eliminates or relieves hyperemia in the outer ocular area, particularly the conjunctival and pericorneal areas. Background technique [0002] Due to physical or chemical stimuli, such as light, burns, smoke, chemical vapors, etc., the bulbar conjunctiva (white of the eye) is easily congested. In addition, blepharitis, conjunctivitis, etc. also cause congestion. To relieve these congestions, commercially available eye drops containing vasoconstrictors are used, which provide a temporary effect. However, hyperemia of the cornea with severe hyperemia of the pericorneal area is caused by inflammation in the cornea, sclera, and uvea, and instillation of vasoconstrictors does not resolve the hyperemia. Even eye drops containing anti-inflammatory drugs such as allantoin, dipotassium glycyrrhizinate, etc., and vasoconstrictor drugs such as naphazoline hydrochloride are not enough to eliminate or relieve the c...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/137A61K31/4164A61K31/436A61K31/44A61K45/06A61P9/08A61P27/14C07D491/052
CPCA61K9/0048A61K45/06A61K31/137A61K31/436A61K31/4164A61K31/44A61P27/02A61P27/14A61P43/00A61P9/08A61K31/00A61K2300/00
Inventor 中山久幸西畑秀一安艺博
Owner SENJU PHARMA CO LTD
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