Zinc fructose-diphosphate and its preparing process and application

A technology of zinc diphosphate and diphosphoric acid, which is applied in the preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc., can solve the problems of no physiological activity, limited therapeutic effect on myocardial ischemia, and inability to treat zinc deficiency, etc. Achieve the effects of improving human cerebral ischemia, improving human immunity, and facilitating absorption and utilization

Inactive Publication Date: 2004-11-24
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the cation of fructose-1,6-bisphosphate sodium salt has no physiological activity, and its therapeutic effect on cerebral ischemia, brain dysfunction, and myocardial ischemia is very limited, and it cannot treat related diseases such as zinc deficiency.

Method used

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  • Zinc fructose-diphosphate and its preparing process and application
  • Zinc fructose-diphosphate and its preparing process and application
  • Zinc fructose-diphosphate and its preparing process and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Take 66.5 grams of fructose-1,6-diphosphate sodium, put it in 100 grams of distilled water, stir until dissolved, slowly pass through the 732-type ion exchange column, collect the effluent, and slowly add 8.9 grams of zinc oxide while stirring at 45°C, When the reaction reaches a pH of 3.0-3.5, filter and freeze-dry the filtrate to obtain 58.5 grams of zinc fructose diphosphate of the present invention. The content of fructose-1,6-bisphosphate is determined by highly specific enzymatic method, and the content of metal ion is determined by chemical method. The result is: fructose-1,6-diphosphate 68.2%, zinc 14.9%, water 15.6%. Press C 6 h 12 o 12 P 2 Zn molecular formula calculation is close to the theoretical value.

Embodiment 2

[0021] Take 1,000 grams of sodium fructose-1,6-diphosphate octahydrate, dissolve it in 1,800 grams of distilled water, slowly pass through a Dowex-type ion exchange column, collect the effluent, take 120 grams of zinc oxide, and slowly add it while stirring at 30°C. React with it to pH 3.0 to 3.5, filter, add the filtrate to 6 times the volume of ethanol, stir, centrifuge, recrystallize the obtained precipitate with ethanol, and finally dry the crystal to obtain the fructose diphosphate of the present invention Zinc 680 grams. The content of fructose-1,6-bisphosphate is determined by highly specific enzymatic method, and the content of metal ion is determined by chemical method. The results were: fructose-1,6-bisphosphate 69.0%, zinc 15.1%, water 14.7%. Press C 6 h 12 o 12 P 2 Zn molecular formula calculation is close to the theoretical value.

Embodiment 3

[0023] Take 200 grams of fructose-1,6-diphosphate sodium, put it in 500 grams of distilled water, stir until dissolved, slowly pass through the 732-type ion exchange column, collect the effluent, take 28.5 grams of zinc oxide, and slowly stir it at 35 ° C. Add, react with it to pH 3.0-3.5, filter, and freeze-dry the filtrate to obtain 185 grams of zinc fructose diphosphate of the present invention. The content of fructose-1,6-bisphosphate is determined by highly specific enzymatic method, and the content of metal ion is determined by chemical method. The result is: fructose-1,6-diphosphate 68.2%, zinc 14.9%, water 15.6%. Press C 6 h 12 o 12 P 2 Zn molecular formula calculation is close to the theoretical value.

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Abstract

A compound fructose-1,6-zinc diphosphate is prepared from fructose-1,6-sodium diphosphate through ion column exchange, reaction on zinc oxide until pH=3-3,5, and post-treating. Said compound has stable property and can be used to prepare the medicine to treat cerebral ischemia (including cerebral disfunction), myocardial ischeme and zinc-deficiency diseases. Its preparing process is simple.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical compounds for treating cerebral ischemia or brain dysfunction, myocardial ischemia and related zinc deficiency diseases, in particular zinc fructose diphosphate and its preparation method and application. Background technique [0002] In modern medicine, fructose-1,6-diphosphoric acid (Fructose-1,6-Diphosphoric Acid) with the following structural formula is an important intermediate of sugar metabolism in the human body, and has the function of regulating sugar metabolism [0003] [0004] role. Fructose-1,6-bisphosphate can improve the energy metabolism of human tissues under ischemia and hypoxia conditions, provide energy for human tissue cells, and relieve cellular glucose metabolism disorders. However, fructose-1,6-bisphosphate itself is very unstable, and it is very difficult to realize its medicinal value. And fructose-1,6-bisphosphate with the following ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7024A61P9/10C07H1/04C07H11/04C12P19/02
Inventor 高勤翁文罗焕敏章佩芬
Owner JINAN UNIVERSITY
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