Application of diethyl ether in resisting African swine fever virus infection

A technology of African swine fever virus and ether, applied in the field of biomedicine, can solve the problems of body poisoning, inability to reach the effective concentration of the virus infection site, body intolerance, etc.

Pending Publication Date: 2022-08-02
邱瑞宝
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, there is currently no anti-ASF virus drug that can effectively inhibit the proliferation of ASF virus in vivo, and the body cannot tolerate heat inactivation above 56°C
The direct use of African swine fever virus inactivator cannot reach the effective concentration at the site of virus infection, and a large amount of use will lead to poisoning of the body

Method used

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  • Application of diethyl ether in resisting African swine fever virus infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Preparation of ether emulsion. Add 10 g of emulsifier phospholipid to 30 g of ether, and stir to dissolve. The fully dissolved ether phospholipid solution is added to 1000 g of water, and stirred at high speed until the emulsification is complete to obtain ether emulsion.

Embodiment 2

[0025] Detection of the effect of ether against viral infection

[0026] Chicken infectious bronchitis virus and African swine fever virus are enveloped viruses, both are sensitive to ether and can be effectively inactivated by ether. The anti-African swine fever virus infection effect of ether preparation was investigated by using the infection model of chicken infectious bronchitis virus.

[0027] Chicks were infected with live vaccine of chicken infectious bronchitis virus H52 strain, and the effect of ether preparation against African swine fever virus was simulated.

[0028] Take 100 7-day-old chicks and divide them into 5 experimental groups, 20 in each group. Group A: the blank control group was not inoculated with the virus and not given any medicine; Group B: the drug control group was only given the medicine but not inoculated with the virus; Group C: the virus control group was inoculated with the virus (vaccinated with live chicken infectious bronchitis vaccine H5...

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PUM

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Abstract

The invention discloses an application of diethyl ether in preparation of an anti-African swine fever virus drug. Targeted dosage forms of diethyl ether are provided.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and particularly relates to the application of ether in anti-African swine fever virus infection drugs. Background technique [0002] African swine fever is an acute, febrile, highly contagious, viral disease of pigs, characterized by a short course of disease but high mortality. [0003] African swine fever virus particles have a diameter of 175-215 nanometers, are icosahedral symmetry, and have an envelope. The virus can replicate rapidly in live pigs. After the pig is infected, the virus can be excreted with the blood, tissue fluid, feces and other excretions of the infected pig, and other healthy pigs will be infected after exposure to these viruses. [0004] Mortality of highly pathogenic strains can be as high as 90-100%; mortality of moderately pathogenic strains is between 20%-40% in adult animals and 70%-80% in juvenile animals ; The mortality rate of low pathogenic strains is betw...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/08A61P31/14
CPCA61K31/08A61P31/14
Inventor 邱瑞宝
Owner 邱瑞宝
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