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Composition for preventing or treating coronavirus infectious diseases comprising low molecular chitosan

A low-molecular-weight chitosan, coronavirus technology, used in medical preparations containing active ingredients, antiviral agents, food science, etc.

Pending Publication Date: 2022-07-22
艾美科健株式会社
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0009] Although there are currently no therapeutic agents approved by the Korean Food and Drug Administration (KFDA), there are products approved for use for therapeutic purposes and products that are undergoing clinical trials

Method used

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  • Composition for preventing or treating coronavirus infectious diseases comprising low molecular chitosan
  • Composition for preventing or treating coronavirus infectious diseases comprising low molecular chitosan
  • Composition for preventing or treating coronavirus infectious diseases comprising low molecular chitosan

Examples

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Embodiment Construction

[0058] Hereinafter, the present invention will be described in detail by the following examples. However, the following examples are only for illustrating the present invention, and the present invention is not limited thereto.

[0059] 1. Intracellular toxicity observation of chitosan oligosaccharide (15kDa)

[0060] To confirm the toxicity of chitosan oligosaccharide and solvent in Vero E6 cells, Vero E6 cells were treated with 4 concentrations of chitosan oligosaccharide and solvent. After 24 hours, phase contrast microscope was used to observe at 20×10 magnification. Phase contrast microscopy (LionHeart FX automated Microscop) pictures were taken 24 hours after Vero E6 cells were treated.

[0061] The result is as figure 1 shown.

[0062] like figure 1 As shown, it was confirmed that 0.1N hydrochloric acid (HCl, Hydrochloric acid) and dimethyl sulfoxide (DMSO, Dimethyl sulfoxide) used as solvents had no cytotoxicity, and when 1% polyethylene glycol was used to confirm ...

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PUM

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Abstract

The present invention relates to a composition for preventing or treating coronavirus infectious diseases comprising low-molecular chitosan or chitosan oligosaccharide, and more particularly, to a composition comprising low-molecular chitosan or chitosan oligosaccharide for preventing or treating coronavirus infectious diseases comprising low-molecular chitosan or chitosan oligosaccharide for preventing or treating diseases caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The present invention relates to a composition for preventing or treating a coronavirus infection disease, which comprises a low molecular weight chitosan or chitosan oligosaccharide having a specific molecular weight range and exhibiting an antiviral effect (Severate response signal coronavius2), and a method for preparing the composition for preventing or treating a coronavirus infection disease by using the composition, and more specifically, to a composition for preventing or treating a coronavirus infection disease by using a low molecular weight chitosan or chitosan oligosaccharide having a specific molecular weight range and having an antiviral effect. The composition containing the low-molecular chitosan or chitosan oligosaccharide in a specific molecular weight range can inhibit translation, replication and proliferation of the severe acute respiratory syndrome coronavirus 2, and can effectively prevent or treat novel coronavirus pneumonia (COVID-19) caused by infection of the severe acute respiratory syndrome coronavirus 2.

Description

technical field [0001] The present invention relates to compositions containing low molecular weight chitosan or chitosan oligosaccharide for preventing or treating coronavirus infection, in more detail, to compositions containing low molecular weight chitosan or chitosan respiratory syndrome coronavirus 2) low molecular weight chitosan or chitosan oligosaccharide with a specific molecular weight range showing antiviral efficacy for preventing or treating the composition of coronavirus infection. Background technique [0002] Infectious diseases are diseases that occur when foreign bodies such as bacteria, bacteria, and viruses begin to appear and inhabit blood, body fluids, and tissues. If they cannot be accurately identified and treated appropriately, life may be lost. Although the prevalence of infectious diseases is on a downward trend with the improvement of hygiene standards, with the abuse of antibiotics, increased use of immunosuppressants due to transplantation, dec...

Claims

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Application Information

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IPC IPC(8): A61K31/722A61P31/14A23L33/125A61K8/73A61Q19/00
CPCA61K31/722A61P31/14A23L33/125A61K8/736A61Q19/00A61K2800/10
Inventor 慎镛哲朴哲柳诚源李多谦张炯瑍郑志嬉
Owner 艾美科健株式会社
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