Injectable sodium alginate/polyvinyl alcohol/dopamine-based hydrogel capable of being rapidly recombined in situ

A technology of polyvinyl alcohol and sodium alginate, which is applied in the direction of medical preparations, prostheses, and aerosol delivery of non-active ingredients, and can solve the problem of limited application, lack of in-situ recombination ability, and lack of injectable performance, etc. problems, to achieve the effect of broadening applications, excellent in-situ and ex-situ self-healing properties, and broad application prospects

Pending Publication Date: 2022-06-28
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the sodium alginate-dopamine / polyvinyl alcohol hydrogel is a stable hydrogel with high mechanical strength, which has almost no injectable properties, and the hydrogel does not have the ability to withstand wet or underwater environments. In situ recombination capability after the injection process, limiting its application as an injectable biomaterial in vivo or in a wet environment

Method used

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  • Injectable sodium alginate/polyvinyl alcohol/dopamine-based hydrogel capable of being rapidly recombined in situ
  • Injectable sodium alginate/polyvinyl alcohol/dopamine-based hydrogel capable of being rapidly recombined in situ
  • Injectable sodium alginate/polyvinyl alcohol/dopamine-based hydrogel capable of being rapidly recombined in situ

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 Preparation of sodium alginate / polyvinyl alcohol / dopamine-based hydrogel

[0037] 1. Preparation of phenylboronic acid-oxidized sodium alginate

[0038]Dissolve 3 g of sodium alginate (SA) in 300 mL of deionized water, then add 1-ethyl-3-(3-(dimethylamino)propyl) carbodiimide hydrochloride (EDC·HCl, 1.305 g ) and N-hydroxysuccinimide (NHS, 0.675g) were added to the above solution and stirred for 15min, then 15mL of dimethyl sulfoxide solution of 3-aminophenylboronic acid (BA, 2.151g) was added, and amidation was carried out under stirring Reaction, after 6 hours of reaction, the above mixed solution was placed in a 12000Da dialysis membrane, dialyzed in deionized water for 3 days, and then freeze-dried to obtain phenylboronic acid-sodium alginate (SA-BA).

[0039] Dissolve 2 g of SA-BA in 100 mL of deionized water, and add 2.5 mL of NaIO dropwise 4 (0.5mmol / L) solution, oxidized for 15min under dark conditions. Subsequently, 5 mL of glycerol was added to te...

Embodiment 2

[0043] Example 2 Preparation of sodium alginate / polyvinyl alcohol / dopamine-based hydrogel

[0044] 1. Preparation of phenylboronic acid-oxidized sodium alginate

[0045] With the step 1 of embodiment 1.

[0046] 2. Preparation of hydrogel

[0047] The sodium alginate / polyvinyl alcohol / dopamine-based hydrogel was prepared by referring to the method in step 2 of Example 1, the only difference being that the mass ratio of PVA, OSA-BA and DA was controlled to be 1:0.443:0.191.

Embodiment 3

[0048] Example 3 Preparation of sodium alginate / polyvinyl alcohol / dopamine-based hydrogel

[0049] 1. Preparation of phenylboronic acid-oxidized sodium alginate

[0050] With the step 1 of embodiment 1.

[0051] 2. Preparation of hydrogel

[0052] The sodium alginate / polyvinyl alcohol / dopamine-based hydrogel was prepared referring to the method in step 2 of Example 1, the only difference being that the mass ratio of PVA, OSA-BA and DA was controlled to be 1:0.148:0.064.

[0053] The beneficial effects of the present invention are demonstrated through experimental examples below.

[0054] The pH value of the phosphate buffer used in the following experiments was 7.2-7.4.

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Abstract

The invention discloses injectable sodium alginate / polyvinyl alcohol / dopamine-based hydrogel capable of being rapidly recombined in situ, and belongs to the field of hydrogel materials. The hydrogel is obtained by blending an aqueous solution of phenylboronic acid modified oxidized sodium alginate and an aqueous solution of a mixture of dopamine and polyvinyl alcohol, and can be rapidly recombined in situ. The hydrogel provided by the invention has excellent in-situ and ectopic self-healing performance in air, water and phosphate buffer environments, so that the hydrogel can be quickly recombined into an original three-dimensional network structure in the air, water and phosphate buffer environments after being injected, and the complete and stable hydrogel is formed again; the application of the hydrogel in a wet environment or in a body is widened. The sodium alginate / polyvinyl alcohol / dopamine-based hydrogel provided by the invention has a wide application prospect in preparation of biological materials applied in vivo.

Description

technical field [0001] The invention belongs to the field of hydrogel materials, in particular to an injectable sodium alginate / polyvinyl alcohol / dopamine-based hydrogel capable of rapid in-situ recombination and a preparation method thereof. Background technique [0002] Hydrogel is a hydrophobic three-dimensional network that can hold a large amount of water or biological fluids. It has strong permeability to oxygen, nutrients, metabolic waste, drug molecules and signal factors. Among them, injectable hydrogel is used as a A biomedical material that can avoid surgical risks and reduce patient discomfort has been extensively studied. Injectable hydrogel has the characteristics of in situ sol-gel transformation, and has potential application prospects in the fields of drug and cell delivery, wound dressing, cartilage repair, bone repair and tissue engineering, and can be used for minimally invasive drug delivery , to accurately fill irregular tissue defects or access diffic...

Claims

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Application Information

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IPC IPC(8): C08L29/04C08L5/04C08K5/18C08J3/075A61K9/06A61K47/36A61K47/32A61L27/20A61L27/16A61L27/52A61L27/50
CPCC08J3/075A61K9/06A61K9/0024A61K47/36A61K47/32A61L27/20A61L27/16A61L27/52A61L27/50A61L2400/06C08J2329/04C08J2405/04C08K5/18C08L5/04C08L29/04
Inventor 吕国玉杜艳李鸿李林杨爱萍
Owner SICHUAN UNIV
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